1,1-Dimethyl-2-(cyclohexylcarbonylamino)ethylamine | 87484-89-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,1-Dimethyl-2-(cyclohexylcarbonylamino)ethylamine
• 英文别名: N-(2-Amino-2-methylpropyl)cyclohexanecarboxamide
• CAS: 87484-89-7
• 化学式: C₁₁H₂₂N₂O
• 分子量: 198.308
• InChiKey: XVYRFJUWUNZDOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,1-Dimethyl-2-(cyclohexylcarbonylamino)ethylamine 生成 ethyl 3-[4-[3-[[1-(cyclohexanecarbonylamino)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]phenyl]propanoate;oxalic acid
  参考文献：
  名称：

  ERHARDT, PAUL W.;MATIER, WILILAM L.

  摘要：

  DOI：

文献信息

• [(Arylcarbonyl)oxy]propanolamines. 1. Novel .beta.-blockers with ultrashort duration of action
  作者：Sheung Tsam Kam、William L. Matier、Khuong X. Mai、Cynthia Barcelon-Yang、Robert J. Borgman、John P. O'Donnell、Herman F. Stampfli、Check Y. Sum、William G. Anderson

  DOI：10.1021/jm00374a013

  日期：1984.8

  Novel [(arylcarbonyl)oxy]propanolamines were synthesized and investigated as potential ultrashort-acting beta-adrenergic receptor blockers. Many of these analogues exhibited good potency and short duration. The N-ureidoalkyl analogue 85 (ACC-9089) has a potency equal to propranolol and a duration of action of about 21 min in the dog. It has been selected as a candidate for further clinical study. Structure-activity relationships and structure-duration relationships for these new beta-blockers are also discussed.
• KAM, SHEUNG T.;MATIER, WILLIAM L.;PATIL, GHANSHYAM;MAI, KHUONG H. X.
  作者：KAM, SHEUNG T.、MATIER, WILLIAM L.、PATIL, GHANSHYAM、MAI, KHUONG H. X.

  DOI：——

  日期：——
• ERHARDT, PAUL W.;MATIER, WILILAM L.
  作者：ERHARDT, PAUL W.、MATIER, WILILAM L.

  DOI：——

  日期：——
• ESTERS OF ARYLOXYPROPANOLAMINE DERIVATIVES AND USE AS BETA-ADRENERGIC BLOCKING AGENTS
  申请人：AMERICAN HOSPITAL SUPPLY CORPORATION

  公开号：EP0093155B1

  公开（公告）日：1986-08-27
• EP0093765A4
  申请人：——

  公开号：EP0093765A4

  公开（公告）日：1984-04-27