(Z)-2-fluoro-4,4-dimethylpent-2-enoic acid | 121318-65-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-2-fluoro-4,4-dimethylpent-2-enoic acid
• CAS: 121318-65-8
• 化学式: C₇H₁₁FO₂
• 分子量: 146.162
• InChiKey: IQCLDYBPZCKMNJ-PLNGDYQASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (Z)-2-fluoro-4,4-dimethylpent-2-enoic acid 在 二异丁基氢化铝 作用下， 以 乙醚 为溶剂， 以81%的产率得到2-fluoro 4,4-dimethyl pent-2-ene 1-ol (Z)
  参考文献：
  名称：

  Préparation d'alcools allyliques fluorés

  摘要：

  DOI：

  10.1016/0022-328x(90)80195-6
• 作为产物：
  描述：

  (Z)-ethyl 2-fluoro-4,4-dimethylpent-2-enoate 生成 (Z)-2-fluoro-4,4-dimethylpent-2-enoic acid
  参考文献：
  名称：

  Pesticidal compounds

  摘要：

  本发明提供了一类具有杀虫活性的新型取代双环辛烷化合物，特别针对节肢动物害虫。还公开了含有式(I)化合物的杀虫配方，以及它们在害虫控制中的使用方法和制备方法。

  公开号：

  US05116862A1

文献信息

• Novel oxadiazole compounds
  申请人：Hobson Adrian D.

  公开号：US20080280876A1

  公开（公告）日：2008-11-13

  Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.

  本发明揭示了新型噁二唑化合物、含有该化合物的药物组合物以及将这些化合物或组合物用作S1P家族G蛋白偶联受体的激动剂或拮抗剂，用于治疗与S1P家族受体活性调节相关的疾病，特别是通过提供有益的免疫抑制效应的疾病。
• TREATING HYPERKALEMIA WITH CROSSLINKED CATION EXCHANGE POLYMERS OF IMPROVED PHYSICAL PROPERTIES
  申请人：Mansky Paul

  公开号：US20100104527A1

  公开（公告）日：2010-04-29

  The present invention is directed to methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio.

  本发明涉及通过给予交联阳离子交换聚合物的药物组合物来除去钾或治疗高钾血症的方法。该药物组合物具有有益的物理特性，包括颗粒大小、颗粒形状、颗粒大小分布、粘度、屈服应力、可压缩性、表面形态和/或肿胀比的组合。
• CROSSLINKED CATION EXCHANGE POLYMERS, COMPOSITIONS AND USE IN TREATING HYPERKALEMIA
  申请人：Mansky Paul

  公开号：US20110236340A1

  公开（公告）日：2011-09-29

  The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.

  本发明涉及交联的带有氟基和酸基的阳离子交换聚合物，这些聚合物的药物组成物，线性多元醇和这种聚合物的盐的组成物。还描述了具有有益物理特性的交联阳离子交换聚合物，包括粒径、粒子形状、粒径分布、粘度、屈服应力、可压缩性、表面形态和/或肿胀比的组合。这些聚合物和组成物有助于在胃肠道中结合钾。
• COMPOSITIONS COMPRISING CROSSLINKED CATION-BINDING POLYMERS AND USES THEREOF
  申请人：Relypsa, Inc.

  公开号：US20150183908A1

  公开（公告）日：2015-07-02

  The present disclosure relates generally to crosslinked cation-binding polymers comprising monomers containing carboxylic acid groups and pKa decreasing groups, wherein the polymer contains i) calcium cations that are counterions to about 5% to about 75% of the carboxylic acid groups in the polymer; or ii) calcium cations and magnesium cations that are counterions to about 5% to about 75% of the carboxylic acid groups in the polymer, wherein the magnesium cations are counterions to no more than about 35% of the carboxylate groups in the polymer. The present disclosure also relates to methods of preparation of the poly mers, and compositions, formulations, and dosage forms containing the polymers, and methods of using the polymers, compositions, formulations, and/or dosage forms to treat various diseases or disorders.

  本公开涉及交联阳离子结合聚合物，该聚合物包含含有羧酸基和pKa降低基的单体，其中聚合物包含i）钙阳离子，其是聚合物中约5％至约75％的羧酸基的对离子；或ii）钙阳离子和镁阳离子，其是聚合物中约5％至约75％的羧酸基的对离子，其中镁阳离子对聚合物中的羧酸盐基不超过约35％。本公开还涉及聚合物的制备方法，以及含有聚合物的组合物、配方和剂量形式，以及使用聚合物、组合物、配方和/或剂量形式治疗各种疾病或障碍的方法。
• NOVEL FLUOROPOLYMER, RESIST COMPOSITIONS CONTAINING THE SAME, AND NOVEL FLUOROMONOMERS
  申请人：Daikin Industries, Ltd.

  公开号：EP1449860A1

  公开（公告）日：2004-08-25

  There is provided a fluorine-containing copolymer having an aliphatic monocyclic structure in the polymer trunk chain which has a number average molecular weight of from 500 to 1,000,000 and is represented by the formula (Ma):         - (M1) - (M2a) - (N) -     (Ma) in which the structural unit M1 is a structural unit derived from an ethylenic monomer having 2 or 3 carbon atoms and at least one fluorine atom, the structural unit M2a is at least one structural unit which introduces an aliphatic monocyclic structure in the polymer trunk chain and is represented by the formula (a): wherein R1 is at least one hydrocarbon group selected from the group consisting of a divalent hydrocarbon group having 1 to 8 carbon atoms and constituting a ring which may be further substituted with a hydrocarbon group or a fluorine-containing alkyl group and a divalent hydrocarbon group having ether bond which has the sum of carbon atoms and oxygen atoms of 2 to 8, constitutes a ring and may be further substituted with a hydrocarbon group or a fluorine-containing alkyl group; R2 is an alkylene group which has 1 to 3 carbon atoms and constitutes a ring; R3 and R4 are the same or different and each is a divalent alkylene group which has 1 or 2 carbon atoms and constitutes a ring; n1, n2 and n3 are the same or different and each is 0 or 1, the structural unit N is a structural unit derived from a monomer copolymerizable with the monomers to introduce the structural units M1 and M2a, and the structural units M1, M2a and N are contained in amounts of from 1 to 99 % by mole, from 1 to 99 % by mole and from 0 to 98 % by mole, respectively. The fluorine-containing polymer possesses excellent dry etching resistance and transparency in a vacuum ultraviolet region.

  有一种含氟共聚物，其聚合物主链具有脂肪族单环结构，其平均分子量为 500 至 1,000,000 之间，由式（Ma）表示： - (M1) - (M2a) - (N) - (Ma) 其中 结构单元 M1 是由具有 2 个或 3 个碳原子和至少一个氟原子的乙烯基单体衍生的结构单元， 结构单元 M2a 是在聚合物主链中引入脂肪族单环结构的至少一个结构单元，由式（a）表示： 其中 R1 是至少一个烃基，该烃基选自以下组别：具有 1 至 8 个碳原子的二价烃基，该烃基构成环，可进一步被烃基或含氟烷基取代；具有醚键的二价烃基，该烃基的碳原子和氧原子之和为 2 至 8，构成环，可进一步被烃基或含氟烷基取代；R2 是具有 1 至 3 个碳原子并构成环的亚烷基； R3 和 R4 相同或不同，且各自是具有 1 或 2 个碳原子并构成环的二价亚烷基； n1、n2 和 n3 相同或不同，且各自为 0 或 1， 结构单元 N 是衍生自可与单体共聚以引入结构单元 M1 和 M2a 的单体的结构单元，且 结构单元 M1、M2a 和 N 的含量分别为 1-99%（摩尔）、1-99%（摩尔）和 0-98%（摩尔）。这种含氟聚合物具有优异的耐干蚀刻性和在真空紫外线区域的透明度。