ethyl 18F-fluoroacetate | 53334-02-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 18F-fluoroacetate
• 英文别名: ethyl 2-(18F)fluoranylacetate
• CAS: 53334-02-4
• 化学式: C₄H₇FO₂
• 分子量: 105.098
• InChiKey: VCYZVXRKYPKDQB-SFIIULIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 18F-fluoroacetate 在 氢氧化钾 作用下， 反应 0.17h， 生成 [18F]-FAC
  参考文献：
  名称：

  An efficient synthesis of Nω-[18F]fluoroacetylserotonin (Nω-[18F]fluoroacetyl-5-hydroxytryptamine)

  摘要：

  本文描述了一种从[18F]氟化物和乙基对甲苯磺酰氧乙酸酯快速合成Nω-[18F]氟乙酰色氨酸（Nω-[18F]氟乙酰-5-羟基色胺）的方法。其合成总时间约为90分钟。所需激素的放射化学产率、纯度和比活度（轰击结束时）分别为13.5%、大于98%和600 mCi/μmol。

  DOI：

  10.1002/jlcr.2580340807
• 作为产物：
  描述：

  2-(甲基磺酰氧基)乙酸乙酯 在 [18F]-tetrabutylammonium fluoride 作用下， 以 乙腈 为溶剂， 反应 0.33h， 生成 ethyl 18F-fluoroacetate
  参考文献：
  名称：

  Synthesis of no-carrier-added [18F]fluoroacetate

  摘要：

  To synthesize no-carrier-added potassium [F-18]fluoroacetate, O-mesyl glycolate ethyl ester and O-tosyl glycolate ethyl ester were synthesized as precursors. These precursors were radiolabeled by reacting with dried tetrabutylammonium [F-18]fluoride in the presence of tetrabutylammonium bicarbonate. O-Mesyl glycolate ethyl ester showed higer F-18 incorporation (77.6% at 100 degrees C) than O-tosyl glycolate ethyl ester (63.2% at 100 degrees C). Resulting [F-18]fluoroacetate ethyl ester was hydrolyzed quantitatively by heating in 1 M potassium hydroxide solution. The [F-18]fluoroacetate was adsorbed to strong anion exchange resin and washed with excess water. Following elution with 1 M sodium bicarbonate solution and passing through Sep-Pak neutral alumina column, the [F-18]fluoroacetate was obtained with 24.5% recovery (non-decay-corrected). Total labeling time from drying F-18 to final product was 70 to 90 min.

  DOI：

  10.1002/(sici)1099-1344(199705)39:5<395::aid-jlcr985>3.0.co;2-4

文献信息

• COX-2-targeted imaging agents
  申请人：Marnett J. Lawrence

  公开号：US20050002859A1

  公开（公告）日：2005-01-06

  The presently disclosed subject matter provides a method for synthesizing a radiological imaging agent by reacting a COX-2-selective ligand with a compound comprising a detectable group, wherein the COX-2-selective ligand is a derivative of a non-steroidal anti-inflammatory drug (NSAID) comprising an ester moiety or a secondary amide moiety. Also provided are compositions that are synthesized using the method, as well as methods of using the compositions of the presently disclosed subject matter.

  目前公开的主题提供了一种合成放射性成像试剂的方法，通过将COX-2选择性配体与含有可检测基团的化合物反应，其中COX-2选择性配体是非甾体抗炎药（NSAID）的衍生物，包括酯基或二级酰胺基团。还提供了使用该方法合成的组合物，以及使用目前公开的主题的组合物的方法。
• TADA, MASAO;OIKAWA, ATSUSHI;IWATA, REN;SATO, KAZUNORI;KUBOTA, KAZUO;FUJIW+, J. LABELL. COMPOUNDS AND RADIOPHARM., 28,(1990) N, C. 847-854
  作者：TADA, MASAO、OIKAWA, ATSUSHI、IWATA, REN、SATO, KAZUNORI、KUBOTA, KAZUO、FUJIW+

  DOI：——

  日期：——
• COENEN, H. H.;SCHUELLER, M.;STOECKLIN, G., J. LABELLED COMPOUNDS AND RADIOPHARM., 1984, 21, N 11-12, 1197-1198
  作者：COENEN, H. H.、SCHUELLER, M.、STOECKLIN, G.

  DOI：——

  日期：——
• BLOCK, DIRK;COENEN, HEINZ HUBERT;STOCKLIN, GERHARD, J. LABELL. COMPOUNDS AND RADIOPHARM., 25,(1988) N 2, 185-200
  作者：BLOCK, DIRK、COENEN, HEINZ HUBERT、STOCKLIN, GERHARD

  DOI：——

  日期：——
• [EN] 18F-FLUORINATED FATTY ACIDS AND USES THEREOF<br/>[FR] ACIDES GRAS 18F-FLUORÉS ET LEURS UTILISATIONS
  申请人：[en]RATIO THERAPEUTICS, INC.

  公开号：WO2024020077A1

  公开（公告）日：2024-01-25

  Disclosed are compounds, compositions, and methods useful for imaging cells in a subject. In particular, the compound have the structure of Formula (I) is useful in the dislocsed imaging methods: