5-[(2S)-thiolan-2-yl]pentanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-[(2S)-thiolan-2-yl]pentanoic acid
• 化学式: C₉H₁₆O₂S
• 分子量: 188.291
• InChiKey: QJMUTWVINYMOBD-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] A PROCESS FOR PRODUCING D-BIOTIN INTERMEDIATES<br/>[FR] PROCÉDÉ DE PRODUCTION D'INTERMÉDIAIRES DE D-BIOTINE
  申请人：DSM IP ASSETS BV

  公开号：WO2021224295A1

  公开（公告）日：2021-11-11

  The present invention provides a process for producing a biotin intermediate compound of formula (I), or a geometrical isomer thereof or a geometrical isomeric mixture thereof in the presence of a catalyst, wherein R1 and R1' are independently H, lower alkyl, aryl or acyl group, optionally substituted by one or more substituents; and R2 is lower alkyl optionally substituted by lower alkoxyl or carboxyl group. According to the present invention, the process surprisingly reduces the reaction pressure while maintaining high yield and selectivity in industrial scale, and thus saves investment on facility and increases safety in industry.