(2S)-1-propan-2-ylpiperazine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-1-propan-2-ylpiperazine-2-carboxamide
• 化学式: C₈H₁₇N₃O
• 分子量: 171.24
• InChiKey: KFELWMUNBBRZOG-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  58.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• PYRIMIDINES AS SODIUM CHANNEL BLOCKERS
  申请人：Purdue Pharma L.P.

  公开号：US20170298027A1

  公开（公告）日：2017-10-19

  The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A 1 , X, A 2 , W 1 , W 2 , W 3 , E, Z, and R 4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
• US9656968B2
  申请人：——

  公开号：US9656968B2

  公开（公告）日：2017-05-23