(E)-3-[5-(4-Bromo-phenyl)-furan-2-yl]-1-(4-chloro-phenyl)-propenone | 294635-97-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (E)-3-[5-(4-Bromo-phenyl)-furan-2-yl]-1-(4-chloro-phenyl)-propenone
• 英文别名: 3-[5-(4-Bromophenyl)furan-2-yl]-1-(4-chlorophenyl)prop-2-en-1-one
• CAS: 294635-97-5
• 化学式: C₁₉H₁₂BrClO₂
• 分子量: 387.66
• InChiKey: NJZWQAKCWPELHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-3-[5-(4-Bromo-phenyl)-furan-2-yl]-1-(4-chloro-phenyl)-propenone 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 7.0h， 生成 1-[5-[5-(4-Bromo-phenyl)-furan-2-yl]-3-(4-chloro-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone
  参考文献：
  名称：

  Studies on arylfuran derivatives

  摘要：

  Arylfurylpropenones 3 were synthesized by Claisen-Schmidt condensation of arylfurfurals 1 with various substituted acetophenones 2. Cyclocondensation of these arylfurylpropenones 3 with hydrazine hydrate and phenylhydrazine furnished 1H-pyrazolines 4 and N-phenylpyrazolines 6, respectively. In order to study the structure-activity relationships, pyrazolines 4 were converted into their N-acetyl derivatives 5. The antibacterial properties of the new pyrazoline derivatives were studied.

  DOI：

  10.1016/s0014-827x(00)00030-6
• 作为产物：
  描述：

  4-溴苯胺 在 盐酸 、 sodium hydroxide 、 sodium nitrite 作用下， 以 乙醇 、 水 为溶剂， 生成 (E)-3-[5-(4-Bromo-phenyl)-furan-2-yl]-1-(4-chloro-phenyl)-propenone
  参考文献：
  名称：

  Synthesis of Novel Arylfurfurylchalcones

  摘要：

  Various aryl furans-2-carbaldehyde chalcones with different acetophenones were prepared and characterized through their elemental analyses and spectroscopic techniques (FTIR, H-1 NMR, C-13 NMR and mass spectra).

  DOI：

  10.14233/ajchem.2013.14590a

文献信息

• Synthesis of Novel Arylfurfurylchalcones
  作者：Samina Aslam、Nadia Asif、Muhammad Naeem Khan、Misbahul Ain Khan、Munawar Ali Munawar、Muhammad Nasrullah

  DOI：10.14233/ajchem.2013.14590a

  日期：——

  Various aryl furans-2-carbaldehyde chalcones with different acetophenones were prepared and characterized through their elemental analyses and spectroscopic techniques (FTIR, H-1 NMR, C-13 NMR and mass spectra).
• Studies on arylfuran derivatives
  作者：B Shivarama Holla、P.M Akberali、M.K Shivananda

  DOI：10.1016/s0014-827x(00)00030-6

  日期：2000.4

  Arylfurylpropenones 3 were synthesized by Claisen-Schmidt condensation of arylfurfurals 1 with various substituted acetophenones 2. Cyclocondensation of these arylfurylpropenones 3 with hydrazine hydrate and phenylhydrazine furnished 1H-pyrazolines 4 and N-phenylpyrazolines 6, respectively. In order to study the structure-activity relationships, pyrazolines 4 were converted into their N-acetyl derivatives 5. The antibacterial properties of the new pyrazoline derivatives were studied.