1-[2-[(2-azaniumylacetyl)amino]acetyl]pyrrolidine-2-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-[2-[(2-azaniumylacetyl)amino]acetyl]pyrrolidine-2-carboxylate
• 化学式: C9H15N3O4
• 分子量: 229.23
• InChiKey: BUEFQXUHTUZXHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• SOLOMONAMIDE ANALOGUE COMPOUNDS, PHARMACEUTICALS CONTAINING SOLOMONAMIDE ANALOGUE COMPOUNDS, AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：US20150291659A1

  公开（公告）日：2015-10-15

  Solomanamide analogues of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogues, including the synthesis of macrocyclic core of Salomanamide analogues. The Solomanamide analogues of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.

  公式I的Solomanamide类似物具有抗炎活性，并且具有制备这种类似物的可行合成路线，包括制备Salomanamide类似物的大环核心的合成。公式I的Solomanamide类似物或其药物盐可以在药物组合物中提供，并以有效剂量用于治疗炎症和/或疼痛。
• A PROCESS FOR THE PREPARATION OF SOLOMONAMIDE ANALOGUES
  申请人：Council of Scientific & Industrial Research

  公开号：EP2925771A1

  公开（公告）日：2015-10-07
• NOVEL NUTRACEUTICAL COMPOSITIONS AND USE THEREOF
  申请人：Edens Luppo

  公开号：US20100166859A1

  公开（公告）日：2010-07-01

  The invention relates to a novel nutraceutical composition containing at least one tripeptide as active ingredient. The term “nutraceutical' as used herein denotes a usefulness in both the nutritional and pharmaceutical field of application. Thus, the novel nutraceutical compositions can find use as supplement to food and beverages, and as pharmaceutical formulations for enteral or parenteral application which may be solid formulations such as capsules or tablets, or liquid formulations, such as solutions or suspensions. As will he evident from the foregoing, the term nutraceutical composition also comprises food and beverages containing the above-specified active ingredients, for example protein hydrolysates which are rich in tripeptides according to the invention. The compositions are useful to improve cognitive functions such as learning, memory and alertness and for the treatment of a disorder connected to impaired neurotransmission and of conditions resulting from hypoxia and for alleviating neuropathic pain.
• US9751911B2
  申请人：——

  公开号：US9751911B2

  公开（公告）日：2017-09-05
• [EN] NOVEL NUTRACEUTICAL COMPOSITIONS AND USE THEREOF<br/>[FR] NOUVELLES PRÉPARATIONS NUTRACEUTIQUES ET APPLICATIONS
  申请人：DSM IP ASSETS BV

  公开号：WO2007079977A2

  公开（公告）日：2007-07-19

  [EN] The invention relates to a novel nutraceutical composition containing at least one tripeptide as active ingredient. The term "nutraceutical" as used herein denotes a usefulness in both the nutritional and pharmaceutical field of application. Thus, the novel nutraceutical compositions can find use as supplement to food and beverages, and as pharmaceutical formulations for enteral or parenteral application which may be solid formulations such as capsules or tablets, or liquid formulations, such as solutions or suspensions. As will be evident from the foregoing, the term nutraceutical composition also comprises food and beverages containing the above-specified active ingredients, for example protein hydrolysates which are rich in tripeptides according to the invention. The compositions are useful to improve cognitive functions such as learning, memory and alertness and for the treatment of a disorder connected to impaired neurotransmission and of conditions resulting from hypoxia and for alleviating neuropathic pain.
  [FR] La présente invention concerne une nouvelle préparation nutraceutique contenant au moins un tripeptide à titre de principe actif. Le terme "nutraceutique" tel qu'employé dans la présente invention désigne une utilité dans les domaines d'application nutritionnel et pharmaceutique. Ainsi, les nouvelles préparations nutraceutiques peuvent être employées en tant que complément d'aliments et de boissons, et en tant que formules pharmaceutiques à usage entéral ou parentéral, qui peuvent être des formules solides telles que des gélules ou des comprimés, ou des formules liquides, telles que des solutions ou des suspensions. Il apparaîtra de façon évidente au vu de ce qui précède que le terme préparation nutraceutique comprend également les aliments et boissons contenant les principes actifs susmentionnés, par exemple des hydrolysats de protéines riches en tripeptides selon l'invention. Les préparations peuvent être employées pour améliorer les fonctions cognitives telles que l'apprentissage, la mémoire et l'attention, ainsi que pour le traitement d'un trouble lié à une neurotransmission défaillante et d'états pathologiques résultant d'une hypoxie, ou encore pour le soulagement d'une douleur névropathique.