N-(2-苯甲酰基-4-氯苯基)-1H-咪唑-1-甲酰胺 | 150878-28-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(2-苯甲酰基-4-氯苯基)-1H-咪唑-1-甲酰胺
• 英文名称: 5-chloro-2-(1-imidazolecarbonylamino)-benzophenone
• 英文别名: N-(2-benzoyl-4-chlorophenyl)-1H-imidazole-1-carboxamide；N-(2-benzoyl-4-chlorophenyl)imidazole-1-carboxamide
• CAS: 150878-28-7
• 化学式: C₁₇H₁₂ClN₃O₂
• 分子量: 325.754
• InChiKey: GILAHYTYEMTUED-UHFFFAOYSA-N

物化性质

• 密度：
  1.33±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-苯甲酰基-4-氯苯基)-1H-咪唑-1-甲酰胺 以 四氢呋喃 、 甲苯 为溶剂， 生成 6-chloro-3-(4-methoxybenzyl)-4-phenyl-2(3H)-quinazolinone
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基-5-氯二苯甲酮 在 N,N'-羰基二咪唑 作用下， 以 二氯甲烷 为溶剂， 以23.2 g (71%)的产率得到N-(2-苯甲酰基-4-氯苯基)-1H-咪唑-1-甲酰胺
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• [EN] QUINAZOLINONE T-TYPE CALCIUM CHANNEL ANTAGONISTS<br/>[FR] ANTAGONISTES DE CANAL CALCIQUE DE TYPE T AU QUINAZOLINONE
  申请人：MERCK & CO INC

  公开号：WO2009009015A1

  公开（公告）日：2009-01-15

  The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及喹唑啉酮类化合物，这些化合物是T型钙通道的拮抗剂，可用于治疗或预防涉及T型钙通道的疾病和疾病。该发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在预防或治疗涉及T型钙通道的疾病中的用途。
• Quinazolinone T-Type Calcium Channel Antagonists
  申请人：Barrow James C.

  公开号：US20080167329A1

  公开（公告）日：2008-07-10

  The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及对T型钙通道具有拮抗作用的喹唑啉酮化合物，其在治疗或预防与T型钙通道有关的疾病和疾病方面具有用途。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗与T型钙通道有关的疾病方面使用这些化合物和组合物。
• Quinazolinone T-type calcium channel antagonists
  申请人：Merck Sharp & Dohme Corp.

  公开号：US07745452B2

  公开（公告）日：2010-06-29

  The present invention is directed to quinazolinone compounds of the formula I: wherein R1, R2, R3, X1, X2 X3 are defined herein. These compounds are antagonists of T-type calcium channels, and are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及式I的喹唑啉酮化合物：其中R1、R2、R3、X1、X2、X3如本文所定义。这些化合物是T型钙通道的拮抗剂，可用于治疗或预防涉及T型钙通道的疾病和疾病。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗涉及T型钙通道的疾病中使用这些化合物和组合物的用途。
• Quinazoline derivatives as inhibitors of HIV reverse transcriptase
  申请人：MERCK & CO. INC.

  公开号：EP0530994A1

  公开（公告）日：1993-03-10

  Compounds having a quinazolin-2-(thi)one nucleus are described. These compounds are useful in the inhibition of HIV reverse transcriptase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

  描述了具有喹唑啉-2-(硫)-1 核的化合物。这些化合物作为化合物、药学上可接受的盐、药物组合物成分，无论是否与其他抗病毒药物、免疫调节剂、抗生素或疫苗结合使用，均可用于抑制 HIV 逆转录酶、预防或治疗 HIV 感染和治疗 AIDS。还描述了治疗艾滋病的方法和预防或治疗艾滋病毒感染的方法。
• WO2006/98969
  申请人：——

  公开号：——

  公开（公告）日：——