N-(3,3-二苯基丙基)乙酰胺 | 17665-85-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(3,3-二苯基丙基)乙酰胺
• 英文名称: N-Acetyl-3,3-diphenylpropylamin
• 英文别名: N-(3,3-Diphenylpropyl)acetamide
• CAS: 17665-85-9
• 化学式: C₁₇H₁₉NO
• 分子量: 253.344
• InChiKey: BEQAMJVWYSBETG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3,3-二苯基丙胺 、 乙醛 在 nickel(II) chloride hexahydrate 、 盐酸羟胺 、 sodium hydroxide 作用下， 以 对二甲苯 为溶剂， 反应 18.0h， 以81%的产率得到N-(3,3-二苯基丙基)乙酰胺
  参考文献：
  名称：

  Catalytic Acylation of Amines with Aldehydes or Aldoximes

  摘要：

  The simple nickel salt NiCl2 center dot 6H(2)O catalyzes the coupling of aldoximes with amines to give secondary or tertiary amide products. The aldoxime can be prepared in situ from the corresponding aldehyde. The use of O-18-labeled oximes has allowed insight into the mechanism of this reaction.

  DOI：

  10.1021/ol101978h

文献信息

• Novel Tetracyclic Tetrahydrofuran Derivatives Containing Cyclic Amine Side Chain
  申请人：Cid-Nunez Jose Maria

  公开号：US20080262076A1

  公开（公告）日：2008-10-23

  This invention concerns novel substituted tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain with binding affinities towards dopamine receptors, in particular dopamine D 2 receptors, towards serotonin receptors, in particular 5-HT 2A and 5-HT 2C receptors, and pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein all substituents are defined as in Claim 1.

  本发明涉及一种新型取代四环四氢呋喃衍生物，其含有一个环状胺侧链，具有结合多巴胺受体的亲和力，特别是多巴胺D2受体，对5-HT2A和5-HT2C受体的亲和力，以及包含根据本发明的化合物的制药组合物，其用作药物，特别是用于预防和/或治疗一系列精神和神经疾病，特别是某些精神病、心血管和胃动力紊乱，并提供其生产过程。根据本发明的化合物可以用一般式（I）表示，并包括其药学上可接受的酸或碱盐、N-氧化物形式或季铵盐，其中所有取代基在权利要求书1中定义。
• ALPHA HELIX MIMETICS AND METHODS RELATING THERETO
  申请人：PRISM BioLab Co., Ltd.

  公开号：US20150368262A1

  公开（公告）日：2015-12-24

  Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the specification, a chemical library relating thereto, and methods relating thereto, are disclosed. Applications of these compounds in the treatment of medical conditions, e.g., cancer diseases, fibrotic diseases, and pharmaceutical compositions comprising the mimetics are further disclosed.

  本文公开了代表公式（I）的α-螺旋类似结构和化合物，其中一般公式和每个符号的定义如规范中所定义，以及与之相关的化学库和方法。还公开了这些化合物在治疗医疗状况（例如癌症疾病、纤维化疾病）中的应用，以及包含这些类似物的制药组合物。
• Improved functionalized resin for chemical synthesis
  申请人：PFIZER INC.

  公开号：EP0801083A2

  公开（公告）日：1997-10-15

  A support functionalized by an indole or pyrrole aldehyde is useful for the solid phase synthesis of amide type compounds.

  吲哚醛或吡咯醛官能化的支持物可用于固相合成酰胺类化合物。
• DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR
  申请人：Galapagos SAS

  公开号：EP2041103A2

  公开（公告）日：2009-04-01
• US8569267B2
  申请人：——

  公开号：US8569267B2

  公开（公告）日：2013-10-29