N-(3,5-二溴-4-羟基苯基)苯磺酰胺 | 51767-46-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(3,5-二溴-4-羟基苯基)苯磺酰胺
• 英文名称: N-(3,5-dibromo-4-hydroxyphenyl)benzenesulfonamide
• 英文别名: benzenesulfonic acid-(3,5-dibromo-4-hydroxy-anilide)；Benzolsulfonsaeure-(3,5-dibrom-4-hydroxy-anilid)；2.6-Dibrom-4-benzolsulfonylamino-phenol；2,6-Dibrom-4-benzolsulfonamidophenol；Benzenesulfonamide, N-(3,5-dibromo-4-hydroxyphenyl)-
• CAS: 51767-46-5
• 化学式: C₁₂H₉Br₂NO₃S
• 分子量: 407.082
• InChiKey: GQORONPQIJQFDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2935009090

反应信息

• 作为反应物：
  描述：

  N-(3,5-二溴-4-羟基苯基)苯磺酰胺 在 lead(IV) acetate 作用下， 以 溶剂黄146 为溶剂， 以99%的产率得到N-(3,5-二溴-4-氧代-2,5-环己二烯-1-亚基)苯磺酰胺
  参考文献：
  名称：

  Avdeenko, A. P.; Velichko, N. V., Journal of Organic Chemistry USSR (English Translation), 1992, vol. 28, # 6.2, p. 986 - 991

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(4-羟苯基)苯磺酰胺 在 potassium dichromate 、 硫酸 、 溴 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-(3,5-二溴-4-羟基苯基)苯磺酰胺
  参考文献：
  名称：

  Avdeenko, A. P.; Velichko, N. V., Journal of Organic Chemistry USSR (English Translation), 1992, vol. 28, # 10.2, p. 1687 - 1692

  摘要：

  DOI：

文献信息

• Photothermographic elements containing a combination of spectral sensitizers
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0742478A1

  公开（公告）日：1996-11-13

  Improved photothermographic elements are spectrally sensitized with a combination of cyanine dyes that provides efficient sensitization together with excellent keeping stability and low dye stain. The photothermographic elements comprise a photosensitive silver halide, an organic silver salt, such as silver behenate, and a reducing agent. The dye combination utilized as a spectral sensitizer for the silver halide is a combination of a first cyanine dye containing two thiazole nuclei and a second cyanine dye containing a thiazole nucleus and an oxazole nucleus.

  改进型光热成像元件采用氰基染料组合进行光谱敏化，可提供高效敏化、出色的保持稳定性和低染料沾污性。光热成像元件由感光卤化银、有机银盐（如山嵛酸银）和还原剂组成。用作卤化银光谱敏化剂的染料组合是含有两个噻唑核的第一种氰基染料和含有一个噻唑核和一个噁唑核的第二种氰基染料的组合。
• Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies
  作者：Steven M. Johnson、Stephen Connelly、Ian A. Wilson、Jeffery W. Kelly

  DOI：10.1021/jm800435s

  日期：2008.10.23

  To develop potent and highly selective transthyretin (TTR) amyloidogenesis inhibitors, it is useful to systematically optimize the three substructural elements that compose a typical TTR kinetic stabilizer: the two aryl rings and the linker joining them. Herein, we evaluated 40 bisaryl molecules based on 10 unique linker substructures to determine how these linkages influence inhibitor potency and selectivity. These linkers connect one unsubstituted aromatic ring to either a 3,5-X 2 or a 3,5-X 2-4-OH phenyl substructure (X = Br or CH 3). Coconsideration of amyloid inhibition and ex vivo plasma TTR binding selectivity data reveal that direct connection of the two aryls or linkage through nonpolar E-olefin or -CH 2CH 2- substructures generates the most potent and selective TTR amyloidogenesis inhibitors exhibiting minimal undesirable binding to the thyroid hormone nuclear receptor or the COX-1 enzyme. Five high-resolution TTR.inhibitor crystal structures (1.4-1.8 A) provide insight into why such linkers afford inhibitors with greater potency and selectivity.
• Halogenated Sulfonanilides
  作者：A. Mooradian、G. W. Leubner

  DOI：10.1021/ja01200a513

  日期：1947.8
• Spectrally sensitized photothermographic elements
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0742477B1

  公开（公告）日：2002-12-11
• Support containing an antihalation dye for use in photothermographic elements
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0919864B1

  公开（公告）日：2004-01-28