5-Amino-1,3-diethylpyrimidine-2,4(1h,3h)-dione | 89073-59-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-Amino-1,3-diethylpyrimidine-2,4(1h,3h)-dione
• 英文别名: 5-amino-1,3-diethylpyrimidine-2,4-dione
• CAS: 89073-59-6
• 化学式: C₈H₁₃N₃O₂
• 分子量: 183.21
• InChiKey: HWSQYEBRQKBJRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(4-Formyl-phenoxy)-hexanoic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 、 5-Amino-1,3-diethylpyrimidine-2,4(1h,3h)-dione 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and mesomorphic behaviour of new mesogenic compounds possessing a cholesteryl ester moiety connected to a pyrimidine core

  摘要：

  New mesogenic compounds containing, a cholesteryl ester and a pyrimidine moiety connected through a polymethylene spacer have been prepared. The mode of linkage has been made via -C=C- and -C=N- to undelstand the structure-property relationship. Only two compounds with a pentamethylene spacer show mesomorphic behaviour. The mesomorphic behaviour has been investigated by polarizing optical microscopy, differential scanning calorimetry and HRXRD studies. Enantiotropic smectic A, twist grain boundary (TGB), and chiral nematic mesophases are exhibited by the newly synthesized compounds. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.02.065

文献信息

• An Efficient Access to Heteroaryl/Aryl-Annulated Pyridine Derivatives and a Study of Their Mosquito Larvicidal Activity Against Dengue Vector
  作者：Pamela Pal、Sayanti Show、Priya Roy、Tapas Ghosh、Raj K. Nandi、Sukanya Das、Sayantika Bhakta、Swarupa Mondal

  DOI：10.1055/a-2251-1849

  日期：——

  convergent synthesis of heteroaryl/aryl-annulated pyridine and quinoline derivatives by a metal-free Povarov reaction. para-Toluene sulfonic acid was used as the catalyst in this reaction, which produced the products in good yields from the corresponding aromatic amines and ethyl vinyl ether. A pyridocoumarin and a pyridopyrimidine product were evaluated for their mosquito larvicidal activity against

  我们报道了通过无金属波瓦洛夫反应聚合合成杂芳基/芳基环化吡啶和喹啉衍生物。该反应采用对甲苯磺酸作为催化剂，由相应的芳香胺和乙基乙烯基醚以良好的产率生成产物。评估了吡啶香豆素和吡啶并嘧啶产品针对登革热媒介蚊子埃及伊蚊的第三龄幼虫的杀蚊子幼虫活性。对幼虫形态变化的检查显示，用 LC 50浓度的吡啶香豆素和吡啶并嘧啶产品处理后，目标身体部位受到损害。
• Substituted 8-phenylxanthines
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0092398A1

  公开（公告）日：1983-10-26

  Substituted 8-phenylxanthines and their use as bronchodilators are described. Processes for their preparation and use as well as pharmaceutical compositions containing them are also described. The novel compounds have the following formula: wherein each of R and R1, which are the same or different, is e.g. a hydrogen atom or an alkyl radical having from to six carbon atoms; the dashed lines mean that the one or two optional substituents may only be in the three and/or four positions; X is e.g. a hydrogen atom; and Y e.g. is OH or an amino group, which amino group may be substituted in a specific way; or a pharmaceutically acceptable salt thereof; with the proviso that the compound 8-(4-sulfophenyl)-theophylline is excluded.

  介绍了取代的 8-苯基黄嘌呤及其作为支气管扩张剂的用途。此外，还介绍了它们的制备和使用方法以及含有它们的药物组合物。这些新型化合物具有下式： 其中，R 和 R1（相同或不同）各为氢原子或具有至六个碳原子的烷基；虚线表示一个或两个任选取代基只能位于三个和/或四个位置；X 为氢原子；Y 为羟基或氨基，其中氨基可以特定方式取代；或其药学上可接受的盐；但不包括化合物 8-(4-磺酸苯基)-茶碱。
• PhI(OAc)2 and BF3–OEt2 mediated heterocyclization: metal-free synthesis of pyrimidine-annulated oxazolines
  作者：Biplab Mondal、Somjit Hazra、Kishor Naktode、Tarun K. Panda、B. Roy

  DOI：10.1016/j.tetlet.2014.08.051

  日期：2014.10

  A simple high yielding and highly efficient synthesis of oxazoline ring fused with uracil moiety is reported. Hypervalent iodine (PIDA) in the presence of BF3-OEt2 generates an effective electrophile to activate uracil C5-C6 double bond leading to heterocyclization. (C) 2014 Elsevier Ltd. All rights reserved.
• STABILISATORZUSAMMENSETZUNGEN FÜR HALOGENHALTIGE POLYMERE MIT VERBESSERTER ANFANGSFARBE UND VERBESSERTER FARBHALTUNG
  申请人：Baerlocher GmbH

  公开号：EP1996649A1

  公开（公告）日：2008-12-03
• STABILIZER COMPOSITIONS FOR HALOGENATED POLYMERS WITH IMPROVED INITIAL COLOR AND IMPROVED COLOR MAINTENANCE
  申请人：Fokken Stefan

  公开号：US20090048374A1

  公开（公告）日：2009-02-19

  A stabilizer composition for halogenated polymers includes at least one compound from group A) and at least one compound from group B), group A) being composed of semicarbazides, carbazides, carbazones, and carbodiazones, and their salts, and group B) of guanidines and melamines, superacids and salts of superacids, epoxy and glycidyl compounds, 1,3-dicarbonyl compounds, polyols, sterically hindered amines, hydrotalcites, zeolites, and alkali metal aluminocarbonates, hydrocalumites, metal hydroxides, metal oxides, metal hydrogen carbonates, and metal carbonates, metal soaps, organotin compounds, organic phosphite esters, amino alcohols and hydroxyl-containing isocyanurates, α,β-unsaturated β-aminocarbonyl compounds, aminouracil compounds and aminothiouracil compounds, and compounds having at least one mercapto-functional, sp 2 -hybridized C atom. Polymers stabilized in accordance with the invention are notable in particular for improved initial color and also for improved color maintenance.