Tert-butyl-[2-[(3-ethenylphenyl)-methoxymethoxy]-3-(trimethylsilylmethyl)but-3-enoxy]-diphenylsilane | 1392422-52-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Tert-butyl-[2-[(3-ethenylphenyl)-methoxymethoxy]-3-(trimethylsilylmethyl)but-3-enoxy]-diphenylsilane
• CAS: 1392422-52-4
• 化学式: C₃₄H₄₆O₃Si₂
• 分子量: 558.908
• InChiKey: CJHVVRPEQMCDTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.83
• 重原子数：
  39
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Tert-butyl-[2-[(3-ethenylphenyl)-methoxymethoxy]-3-(trimethylsilylmethyl)but-3-enoxy]-diphenylsilane 在 [双(三氟甲磺酰基)氨基]三甲基硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 生成 、
  参考文献：
  名称：

  Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside

  摘要：

  2-Deoxy-C-nucleosides are a subcategory of C-nucleosides that has not been explored extensively, largely because the synthesis is less facile. Flexible synthetic procedures giving access to 2-deoxy-C-nucleosides are therefore of interest. To exemplify the versatility and highlight the limitations of a synthetic route recently developed to that effect, the first synthesis of 2-deoxy benzamide riboside is reported. Biological properties of this novel C-nucleoside are also discussed. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.06.069
• 作为产物：
  描述：

  4-(trimethylsilyl)-3-methylenebutane-1,2-diol 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 Tert-butyl-[2-[(3-ethenylphenyl)-methoxymethoxy]-3-(trimethylsilylmethyl)but-3-enoxy]-diphenylsilane
  参考文献：
  名称：

  Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside

  摘要：

  2-Deoxy-C-nucleosides are a subcategory of C-nucleosides that has not been explored extensively, largely because the synthesis is less facile. Flexible synthetic procedures giving access to 2-deoxy-C-nucleosides are therefore of interest. To exemplify the versatility and highlight the limitations of a synthetic route recently developed to that effect, the first synthesis of 2-deoxy benzamide riboside is reported. Biological properties of this novel C-nucleoside are also discussed. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.06.069

文献信息

• Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside
  作者：Rebecca R. Midtkandal、Philip Redpath、Samuel A.J. Trammell、Simon J.F. Macdonald、Charles Brenner、Marie E. Migaud

  DOI：10.1016/j.bmcl.2012.06.069

  日期：2012.8

  2-Deoxy-C-nucleosides are a subcategory of C-nucleosides that has not been explored extensively, largely because the synthesis is less facile. Flexible synthetic procedures giving access to 2-deoxy-C-nucleosides are therefore of interest. To exemplify the versatility and highlight the limitations of a synthetic route recently developed to that effect, the first synthesis of 2-deoxy benzamide riboside is reported. Biological properties of this novel C-nucleoside are also discussed. (c) 2012 Elsevier Ltd. All rights reserved.