12-[2,6-dimethoxy-4-[(E)-2-(4-methoxyphenyl)ethenyl]phenyl]dodecan-1-ol | 948052-39-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 12-[2,6-dimethoxy-4-[(E)-2-(4-methoxyphenyl)ethenyl]phenyl]dodecan-1-ol
• CAS: 948052-39-9
• 化学式: C₂₉H₄₂O₄
• 分子量: 454.65
• InChiKey: JEFLKIPAABWSFK-FOCLMDBBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  33
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  12-[2,6-dimethoxy-4-[(E)-2-(4-methoxyphenyl)ethenyl]phenyl]dodecan-1-ol 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 2-(12-hydroxydodecyl)-5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
  参考文献：
  名称：

  Dual bioactivity of resveratrol fatty alcohols: Differentiation of neural stem cells and modulation of neuroinflammation

  摘要：

  The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and (omega-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.037
• 作为产物：
  描述：

  tert-butyl(dodec-11-ynyloxy)dimethylsilane 在 bis-triphenylphosphine-palladium(II) chloride 、 palladium on activated charcoal 盐酸 、 copper(l) iodide 、 lithium aluminium tetrahydride 、 N-甲基吲哚酮 、 四丙基高钌酸铵 、 氢气 、 sodium methylate 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 47.0h， 生成 12-[2,6-dimethoxy-4-[(E)-2-(4-methoxyphenyl)ethenyl]phenyl]dodecan-1-ol
  参考文献：
  名称：

  Dual bioactivity of resveratrol fatty alcohols: Differentiation of neural stem cells and modulation of neuroinflammation

  摘要：

  The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and (omega-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.037

文献信息

• Hydroxylated Long-Chain Resveratrol Derivatives Useful as Neurotrophic Agents
  申请人：Luu Bang

  公开号：US20100048731A1

  公开（公告）日：2010-02-25

  The present invention relates to a compound of general formula (I) below in which R 1 , R 2 and R 3 represent, independently of one another, a hydrogen atom or a C 1 -C 6 alkyl group or a (C 1 -C 6 alkyl)carbonyl group, R 4 , R 5 , R 6 and R 7 represent a hydrogen or a C 1 -C 6 alkyl group, a C1-C6 alkoxy group or a (C 1 -C 6 alkyl)carbonyloxy group, and n is an integer between 8 and 20, or its pharmaceutically acceptable addition salts, isomers, enantiomers and diastereoisomers, and also mixtures thereof. The invention also relates to a pharmaceutical composition comprising the compound and to the use thereof as a neurotrophic agent.

  本发明涉及以下通式（I）中的化合物，其中R1、R2和R3分别独立地表示氢原子或C1-C6烷基或（C1-C6烷基）羰基，R4、R5、R6和R7表示氢或C1-C6烷基、C1-C6烷氧基或（C1-C6烷基）羰氧基，n为8至20之间的整数，或其药学上可接受的加合盐、异构体、对映体和非对映体，以及它们的混合物。该发明还涉及包含该化合物的药物组合物以及其作为神经营养因子的用途。
• Dual bioactivity of resveratrol fatty alcohols: Differentiation of neural stem cells and modulation of neuroinflammation
  作者：Frédérique Hauss、Jiawei Liu、Alessandro Michelucci、Djalil Coowar、Eleonora Morga、Paul Heuschling、Bang Luu

  DOI：10.1016/j.bmcl.2007.05.037

  日期：2007.8

  The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and (omega-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies. (c) 2007 Elsevier Ltd. All rights reserved.