2-(2-propoxyphenoxy)-N-(1,3-thiazol-2-yl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(2-propoxyphenoxy)-N-(1,3-thiazol-2-yl)acetamide
• 化学式: C₁₄H₁₆N₂O₃S
• 分子量: 292.36
• InChiKey: WQRBLWCFKDYPSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  88.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• SMALL MOLECULE MODULATORS OF MHC-I
  申请人：RetroVirox, Inc.

  公开号：US20220411419A1

  公开（公告）日：2022-12-29

  The invention disclosed herein are embodiments of compounds capable of treating a viral infection. For example, the compounds are capable of inhibiting viral downmodulation of major histocompatibility complex I (MHC-I), such as by acting as immunomodulators of the immune system to treat, cure or eradicate a viral infection (e.g., HIV infection). More particularly, the present disclosure relates to the use of a heteroaryl compound or salts or analogs thereof, in the treatment of patients infected with a virus. The disclosed compounds may be used alone or in combination with other pharmacologically active agents to treat, cure or eradicate the virus, particularly in patients with persistent, latent viral infection. In some embodiments, the disclosed compounds can be used alone or in combination with other pharmacologically active agents to promote reactivation of viral production in latent cells and eradication of such cells.