N-(4,6-dimethyl-pyrimidin-2-yl)-N'-phenethyl-guanidine | 55474-82-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(4,6-dimethyl-pyrimidin-2-yl)-N'-phenethyl-guanidine
• 英文别名: N-(4,6-Dimethyl-2-pyrimidinyl)-N'-(2-phenylethyl)guanidine；1-(4,6-dimethylpyrimidin-2-yl)-2-(2-phenylethyl)guanidine
• CAS: 55474-82-3
• 化学式: C₁₅H₁₉N₅
• 分子量: 269.349
• InChiKey: FVBRWQIUJUHLKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  76.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Heataryl-substituted guanidine compounds and use thereof as binding partners for 5-ht5-receptors
  申请人：Amberg Wilhelm

  公开号：US20100184787A1

  公开（公告）日：2010-07-22

  The invention relates to the hetaryl-substituted guanidine compounds of general formula (I), enantiomeres, diastereomeres and/or tautomeres thereof, in addition to the pharmaceutically acceptable salts thereof and the prodrugs of the known compounds. The invention also relates to the use of said hetaryl-substituted guanidine compounds as binding partners for 5-HT5-receptors for treating and/or for the prophylaxis of illnesses which are modulated by a 5-HT5-receptor activity, in particular, for treating and/or for the prophylaxis of neurodegenerative and neuropsychiatric disorders, and signs, symptoms and dysfunctions associated with said disorders.

  该发明涉及一般式(I)的杂环取代胍胺化合物，以及其对映体、非对映体和/或互变异构体，以及其药学上可接受的盐和已知化合物的前药。该发明还涉及将所述杂环取代胍胺化合物用作5-HT5受体的结合伙伴，用于治疗和/或预防由5-HT5受体活性调节的疾病，特别是用于治疗和/或预防神经退行性和神经精神障碍，以及与该类障碍相关的症状、体征和功能障碍。
• Compounds and methods for inhibition of HIV and related viruses
  申请人：Medivir AB

  公开号：US20040116418A1

  公开（公告）日：2004-06-17

  The present invention is directed to compounds, compositions and methods of inhibiting and treating HIV and related viruses, and methods for cocrystallizing reverse transcriptase in vitro, inhibition of the replication of HIV and related viruses thereof.

  本发明涉及抑制和治疗HIV及相关病毒的化合物、组合物和方法，以及体外共结晶逆转录酶的方法，抑制HIV及相关病毒的复制。
• COMPOUNDS AND METHODS FOR INHIBITION OF HIV AND RELATED VIRUSES
  申请人：MEDIVIR AB

  公开号：EP0706514A1

  公开（公告）日：1996-04-17
• US5849769A
  申请人：——

  公开号：US5849769A

  公开（公告）日：1998-12-15
• US6376492B1
  申请人：——

  公开号：US6376492B1

  公开（公告）日：2002-04-23