2-oxo-1-phenyl-1,2-dihydro-pyrimidine-5-carboxylic acid amide | 1233198-71-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-oxo-1-phenyl-1,2-dihydro-pyrimidine-5-carboxylic acid amide
• 英文别名: 2-Oxo-1-phenylpyrimidine-5-carboxamide
• CAS: 1233198-71-4
• 化学式: C₁₁H₉N₃O₂
• 分子量: 215.211
• InChiKey: ZPCCDJHKEDWTBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-formyl-3-(3-phenylureido)acrylamide 在 potassium tert-butylate 作用下， 以 甲醇 为溶剂， 以90%的产率得到2-oxo-1-phenyl-1,2-dihydro-pyrimidine-5-carboxylic acid amide
  参考文献：
  名称：

  Novel and Efficient Synthesis of Pyrimidine Derivatives

  摘要：

  A new series of 1-alkyl-2-oxo-1,2-dihydro-pyrimidine-5-carboxalic acid amides is described. The reaction of N-((E)-3-(dimethylamino)-2-formylacryloyl) formamidine, an intermediate obtained by Vilsmeier-Haack formylation of acetonitrile with various mono-substituted ureas, provides such compounds in good yields.

  DOI：

  10.1080/00397910903108521

文献信息

• Novel and Efficient Synthesis of Pyrimidine Derivatives
  作者：Maruti G. Ghagare、Dilip R. Birari、Deepak P. Shelar、Raghunath B. Toche、Madhukar N. Jachak

  DOI：10.1080/00397910903108521

  日期：2010.5.11

  A new series of 1-alkyl-2-oxo-1,2-dihydro-pyrimidine-5-carboxalic acid amides is described. The reaction of N-((E)-3-(dimethylamino)-2-formylacryloyl) formamidine, an intermediate obtained by Vilsmeier-Haack formylation of acetonitrile with various mono-substituted ureas, provides such compounds in good yields.