1-Azacyclodecane-2,10-dione | 144760-69-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Azacyclodecane-2,10-dione
• 英文别名: Heptanedicarboximide；azecane-2,10-dione
• CAS: 144760-69-0
• 化学式: C₉H₁₅NO₂
• 分子量: 169.224
• InChiKey: HUXSAESWQBPYHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Allyl 1-allyl-2,10-dioxo-1-azacyclodecane-3-carboxylate 在 四(三苯基膦)钯 、 甲酸 、 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 以75%的产率得到1-Azacyclodecane-2,10-dione
  参考文献：
  名称：

  Synthesis of MacrocyclicN-Unsubstituted Imides

  摘要：

  本文介绍了一种从环烷酮制备迄今未报道的 N-未取代环烷二甲酰胺的合成方法。 该方法包括在温和的条件下进行双原子扩环，然后进行 N-脱烯丙基化反应，从而得到高产率的产品。

  DOI：

  10.1055/s-1992-26265

文献信息

• A Process for Preparing Olodaterol and Intermediates Thereof
  申请人：REDDY G. Pratap

  公开号：US20170260149A1

  公开（公告）日：2017-09-14

  The present invention relates to a process for preparing olodaterol and intermediates thereof. The process comprises of forming compound of Formula 1 by reacting compound of Formula 2 or its acid salt with compound of Formula 3 in the presence of an organic solvent to obtain compound of Formula 4. Protecting groups are removed from compound of Formula 4 in the presence of a suitable solvent to form compound of Formula 1.

  本发明涉及一种制备奥洛达特罗及其中间体的方法。该方法包括通过在有机溶剂存在下，将化合物Formula 2或其酸盐与化合物Formula 3反应形成化合物Formula 1，从而获得化合物Formula 4。在适当溶剂的存在下，从化合物Formula 4中去除保护基，形成化合物Formula 1。
• Method for producing alpha-olefin low polymer
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US10221109B2

  公开（公告）日：2019-03-05

  The present invention relates to a method for producing an α-olefin low polymer through low polymerization reaction of an α-olefin in the presence of a catalyst containing a transition metal-containing compound, an aluminum-containing compound and a hydrocarbon having 2 or more carbon atoms and substituted with a halogen atom, and a solvent, which comprises a reaction step, a purification step and a circulation step of circulating the unreacted raw material α-olefin and the solvent from the purification step to the reaction step; and in which the amount of the olefin having 2 or more carbon atoms and substituted with a halogen atom that is supplied from the circulation step to the reaction step is within a range of from 0.1 to less than 200 (molar ratio) relative to the amount of the transition metal in the reaction step.

  本发明涉及一种生产α-烯烃低聚物的方法，该方法是通过α-烯烃在含过渡金属化合物、含铝化合物和具有2个或2个以上碳原子并被卤素原子取代的碳氢化合物以及溶剂的催化剂存在下进行低聚合反应来生产α-烯烃低聚物，该方法包括反应步骤、纯化步骤和将未反应的原料α-烯烃和溶剂从纯化步骤循环到反应步骤的循环步骤；其中从循环步骤供应到反应步骤的具有 2 个或 2 个以上碳原子并被卤素原子取代的烯烃的量在 0.1至小于200（摩尔比）的范围内。
• Multifunctionalized polyethylene glycol derivative and preparation method therefor
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US11324827B2

  公开（公告）日：2022-05-10

  Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n1, n2, n3, and n4 respectively are the degrees of polymerization of the branch chains, U1 and U2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F1 and F2 contain a functional group or a protected form R01 thereof and may or may not contain a branched group G, correspondingly, the number of R01 is one or more, F1 and F2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.

  本发明公开了一种多功能聚乙二醇衍生物及其制备方法。该衍生物具有由式（1）表示的 H 型结构，包括一个线性核心 LPEG 和四个 PEG 支链，其中 n1、n2、n3 和 n4 分别为支链的聚合度，U1 和 U2 为连接核心 LPEG 和两个 PEG 支链的三价支化基团、F1 和 F2 含有一个官能团或其保护形式 R01，可以含有或不含有支链基团 G，相应地，R01 的数目为一个或多个，F1 和 F2 要么相同要么不同，分子中的任何一个连接基团或与相邻杂原子基团形成的任何连接基团要么保持稳定，要么降解，分子中的任何一个 PEG 段离散多分散或单分散。多功能聚乙二醇的支链结构和支臂长度灵活多样，各种参数和性能指标可调且易于控制，具有广泛的适用性。
• SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP3013814B1

  公开（公告）日：2017-06-14
• METHOD FOR PRODUCING ALPHA-OLEFIN LOW POLYMER
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US20160362350A1

  公开（公告）日：2016-12-15

  The present invention relates to a method for producing an α-olefin low polymer through low polymerization reaction of an α-olefin in the presence of a catalyst containing a transition metal-containing compound, an aluminium-containing compound and a hydrocarbon having 2 or more carbon atoms and substituted with a halogen atom, and a solvent, which comprises a reaction step, a purification step and a circulation step of circulating the unreacted raw material α-olefin and the solvent from the purification step to the reaction step; and in which the amount of the olefin having 2 or more carbon atoms and substituted with a halogen atom that is supplied from the circulation step to the reaction step is within a range of from 0.1 to less than 200 (molar ratio) relative to the amount of the transition metal in the reaction step.