Ddz-D-Ala-OH | 115545-84-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ddz-D-Ala-OH
• 英文别名: (2R)-2-[2-(3,5-dimethoxyphenyl)propan-2-yloxycarbonylamino]propanoic acid
• CAS: 115545-84-1
• 化学式: C₁₅H₂₁NO₆
• 分子量: 311.335
• InChiKey: DQYVXSMGPCFHSK-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  94.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Ddz-D-Ala-OH 、 S-trityl-L-cysteine methyl ether 以36%的产率得到
  参考文献：
  名称：

  ZANOTTI, GIANCARLO;BEIJER, BARBRO;WIELAND, THEODOR, INT. J. PEPTIDE AND PROTEIN RES., 30,(1987) N 3, 323-329

  摘要：

  DOI：

文献信息

• Efficient parallel synthesis of macrocyclic peptidomimetics
  作者：Eric Marsault、Hamid R. Hoveyda、René Gagnon、Mark L. Peterson、Martin Vézina、Carl Saint-Louis、Annick Landry、Jean-François Pinault、Luc Ouellet、Sophie Beauchemin、Sylvie Beaubien、Axel Mathieu、Kamel Benakli、Zhigang Wang、Martin Brassard、David Lonergan、François Bilodeau、Mahesh Ramaseshan、Nadia Fortin、Ruoxi Lan、Shigui Li、Fabrice Galaud、Véronique Plourde、Manon Champagne、Annie Doucet、Patrick Bhérer、Maude Gauthier、Gilles Olsen、Gérald Villeneuve、Shridhar Bhat、Laurence Foucher、Daniel Fortin、Xiaowen Peng、Sylvain Bernard、Alexandre Drouin、Robert Déziel、Gilles Berthiaume、Yves L. Dory、Graeme L. Fraser、Pierre Deslongchamps

  DOI：10.1016/j.bmcl.2008.06.085

  日期：2008.8

  A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A key feature of the method is access to broad chemical and conformational diversity. Synthesis and mechanistic studies on the macrocyclization step are reported.

  报道了一种化学和构象多样的大环拟肽的固相平行合成的新方法。该方法的关键特征是获得广泛的化学和构象多样性。报道了有关大环化步骤的合成和机理研究。
• Preparation of Photoactivable Amino Acid Derivatives
  作者：Jean-Luc Débieux、Christian G. Bochet

  DOI：10.1021/jo900442p

  日期：2009.6.19

  A range of N-protected-alpha-amino acyl-5,7-dinitroindolines 3a-z were prepared in good yields from commercially available N-protected-alpha-amino acids 1a-z by a two-step sequence of acylation and intramolecular amide N-arylation. Subsequent photochemical acylation of the N-protected-alpha-amino acyl-5,7-dinitroindolines 3e,g,r afforded the corresponding N-protected-alpha-amino acid amides 22e,g,r (77-92%) under mild conditions. All these reactions occurred with complete retention of chirality as evidenced by NMR analysis. This scheme provides an attractive and alternative method to the conventional acylation of alpha-amino acids, especially in cases where the amide bond needs to be formed without the use of a coupling reagent.
• ZANOTTI, GIANCARLO;BEIJER, BARBRO;WIELAND, THEODOR, INT. J. PEPTIDE AND PROTEIN RES., 30,(1987) N 3, 323-329
  作者：ZANOTTI, GIANCARLO、BEIJER, BARBRO、WIELAND, THEODOR

  DOI：——

  日期：——