N-(4-氨基-3-硝基苯基)二乙醇胺 | 29705-39-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-氨基-3-硝基苯基)二乙醇胺
• 英文名称: 2,2'-[(4-amino-3-nitrophenyl)imino]bis[ethanol]
• 英文别名: HCRed13；2-nitro-1-amino-4-[bis-(2-hydroxyethyl)-amino]-benzene；4-(di-(2-hydroxyethyl)amino)-2-nitroaniline；1-amino-2-nitro-4-[bis(2-hydroxyethyl)]aminobenzene；2-amino-5-[N,N-bis(β-hydroxyethyl)amino]nitrobenzene；1-amino-2 nitro-4-bis(β-hydroxyethyl)-aminobenzene；1-amino-4-[di(2'-hydroxyethyl)amino]-2-nitrobenzene；2,2'-[(4-Amino-3-nitrophenyl)imino]bisethanol；2-[4-amino-N-(2-hydroxyethyl)-3-nitroanilino]ethanol
• CAS: 29705-39-3
• 化学式: C₁₀H₁₅N₃O₄
• 分子量: 241.247
• InChiKey: VOLCMGPDRGNUGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  116
• 氢给体数：
  3
• 氢受体数：
  6

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  N-(4-氨基-3-硝基苯基)二乙醇胺 在 Ru-carbon 一水合肼 作用下， 以 乙醇 为溶剂， 反应 1.5h， 以90%的产率得到2,2'-[(3,4-diaminophenyl)imino]bis[ethanol]
  参考文献：
  名称：

  Labelling of Carbaboranyl Compounds with a Selenium Atom with a View to Applications in Boron-Neutron-Capture Therapy (BNCT) and Positron-Emission Tomography (PET)

  摘要：

  We synthesized 2'-carbaboranyl-2,5'-bi-1H-benzimidazoles containing 10 B-atoms and labeled with Se or the positron-emitting radionuclide Se-73 (t(1/2) = 7.1 h), with a view to their application to cancel. treatment by boron-neutron-capture therapy (BNCT) and to compound-distribution measurements in vivo by positron-emission tomography (PET). Thus, 2,2'-{[2'-(4-[1,2-dicarba-closo-dodecaboran(12)-2-ylmethoxy]phenyl]-[2,5'-bi-1H-benzimidazol]-5-yl}imino)bis[ethanol] (26c) was obtained by the reaction of 2,2'-[(3,4-diaminephenyl)imino]bis[ethanol] (19) with ethyl 2-{4-[1,2-dicarba-closo-dodecaboran(12)-2-ylmethoxy]phenyl}-1H-benzimidazole-5-carboximidate hydrochloride (25), as well as the analogues 26a and 26b (Scheme 6). Tosylation of compound 26c gave 4 regioisomers 27a-d, which, after selenation, produced 2'-{4-[1,2-dicarba-closo-dodecaboran(12)-2-ylmethoxy]phenyl}-5-(tetrahydro-2H-1,4-selenazin-4-yl)-2,5'-bi-1H-benzimidazole (29) in 42% yield (Scheme 7).

  DOI：

  10.1002/1522-2675(20001108)83:11<2926::aid-hlca2926>3.0.co;2-6
• 作为产物：
  描述：

  3-硝基-4-[N-(2-羟乙基)氨基]-N,N-二(2-羟乙基)苯胺 在 ammonium hydroxide 、 sodium sulfite 作用下， 以 甲醇 为溶剂， 反应 144.0h， 以80%的产率得到N-(4-氨基-3-硝基苯基)二乙醇胺
  参考文献：
  名称：

  Unusual reaction of 1,4-diamino-2-nitrobenzene derivatives toward nucleophiles: Catalysis by sodium sulphite

  摘要：

  Unusual substitution of amino group occurs by reactions of some 1,4-diamino-2-nitrobenzenes (semipermanent hair dyes) and nucleophiles (NH3, H2O). The reaction is catalyzed by sodium sulfite. The obtained products are suspected of being toxic substances which may he present in cosmetic matrices. Apparently, this reaction is a nucleophilic aromatic substitution hut it may be explained by a mechanism involving a tautomeric form of substrate. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00181-1

文献信息

• COLORING AGENTS AND METHODS OF USE THEREOF
  申请人：Living Proof, Inc.

  公开号：US20160106648A1

  公开（公告）日：2016-04-21

  Dyes, compositions comprising dyes and methods for using the same are provided.

  染料、包含染料的组合物以及使用这些染料的方法。
• Novel p-aminophenol derivatives and the use thereof
  申请人：——

  公开号：US20010004779A1

  公开（公告）日：2001-06-28

  The present invention relates to new p-aminophenol derivatives and to methods of using the same for coloring keratin fibers. The present invention also relates to colorant compositions containing these compounds.

  本发明涉及新的对氨基苯酚衍生物以及使用这些衍生物为角蛋白纤维着色的方法。本发明还涉及含有这些化合物的着色剂组合物。
• Polycationic monochromophoric hydrazone compounds, dye compositions comprising such polycationic compounds and dyeing process using them
  申请人：David Herve

  公开号：US20080263785A1

  公开（公告）日：2008-10-30

  The present disclosure relates to polycationic monochromophoric hydrazone compounds of following formula (I): wherein W 1 is a heteroaromatic radical comprising 5 or 6 ring members, optionally condensed with an aromatic ring comprising 6 ring members, comprising a quaternized nitrogen atom and optionally another heteroatom which may or may not be identical to nitrogen; X, which may or may not be identical, is a nitrogen atom or a CR 2 group; Z is a cationic group comprising at least one quaternized nitrogen atom. The present disclosure also relates to a composition for dyeing human keratin fibers comprising the polycationic compounds disclosed herein, and to a dyeing process using the composition of the present disclosure, and even further to multicompartment device.

  本公开涉及以下式（I）的多阳离子单色基醛肼化合物： 其中W1是包括5或6个环成员的杂环芳基，可选择地与包括6个环成员的芳香环融合，包括一个季铵化氮原子和可选择的可能与氮不同的另一个杂原子；X，可能相同也可能不同，是一个氮原子或一个CR2基团；Z是包括至少一个季铵化氮原子的阳离子基团。 本公开还涉及一种用于染色人类角蛋白纤维的组合物，包括本公开披露的多阳离子化合物，以及使用本公开的组合物进行染色的过程，甚至进一步涉及多室装置。
• Dicationic bis-hydrazone compound, dye composition comprising at least one such compound, implementation process therefor and uses thereof
  申请人：David Herve

  公开号：US20060096043A1

  公开（公告）日：2006-05-11

  The present disclosure relates to a novel family of dicationic bis-hydrazone compounds that may be used as direct dyes, and to a dye composition for dyeing keratin fibers, for example, human keratin fibers such as the hair, comprising, in a suitable dyeing medium, at least one such compound. Also disclosed are dyeing processes implementing this composition and uses thereof.

  本公开涉及一种新型的双阳离子双肼酮化合物家族，可用作直接染料，以及用于染色角蛋白纤维的染料组合物，例如人类角蛋白纤维如头发，包括在适当的染色介质中至少含有一种这样的化合物。还公开了实施该组合物的染色过程和用途。
• Dyeing composition comprising at least one disulphide dye and method of dyeing human keratin fibers using this dye
  申请人：Daubresse Nicolas

  公开号：US20060080791A1

  公开（公告）日：2006-04-20

  Disclosed herein is a dyeing composition comprising a particular disulphide dye and a method of dyeing human keratin fibers, such as hair, using this composition. This composition makes it possible to obtain particularly fast chromatic colorations.

  本文揭示了一种染色组合物，包括特定的二硫化染料，以及使用该组合物染色人类角蛋白纤维（如头发）的方法。该组合物使得可以获得特别快速的彩色染色效果。