Methyl 4-(dipropylamino)-4-oxobutanoate | 6942-25-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Methyl 4-(dipropylamino)-4-oxobutanoate
• CAS: 6942-25-2
• 化学式: C₁₁H₂₁NO₃
• 分子量: 215.29
• InChiKey: QGGNFKXNQVFBML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS
  申请人：ZHAO R. Yongxin

  公开号：US20170157262A1

  公开（公告）日：2017-06-08

  A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a formula (I), wherein T, L, m, n, Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 12 , and R 13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

  一种具有公式（I）的细胞表面受体结合分子的强效细胞毒药物的共轭物，其中T、L、m、n、Y、R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R12和R13在此定义，可用于靶向治疗癌症、自身免疫疾病和传染病。
• Conjugates of Cell Binding Molecules with Cytotoxic Agents
  申请人：Zhao R. Yongxin

  公开号：US20170296663A1

  公开（公告）日：2017-10-19

  A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , and R 13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

  一种有效的细胞毒性药物的共轭物，带有具有化学式（I）的细胞表面受体结合分子，其中T、L、m、n、R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12和R13在此有定义，可用于靶向治疗癌症、自身免疫疾病和传染性疾病。
• Perfluorinated t-amino cyclic ethers
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0492823A2

  公开（公告）日：1992-07-01

  Perfluorinated, t-amino cyclic ethers are provided. Electrochemical fluorination of N,N-dialkyl carboxamides provides Class 1 compounds of one or a mixture of perfluorinated, N-alkyl, aliphatic-substituted, saturated 1,3-oxazolidine and perfluorinated, N-alkyl, aliphatic-substituted, saturated 1,3-oxazine. Class 2 compounds comprise one or a mixture of Class 1 compounds, as well as perfluorinated, aliphatic-substituted 2-dialkylaminotetrahydrofuran and perfluorinated, aliphatic-substituted 2-dialkylamino dihydropyran.

  提供了全氟 t-氨基环醚。N,N-二烷基羧酰胺的电化学氟化提供了第 1 类化合物，即全氟 N-烷基、脂肪族取代的饱和 1,3-恶唑烷和全氟 N-烷基、脂肪族取代的饱和 1,3-恶嗪的一种或混合物。第 2 类化合物包括第 1 类化合物的一种或混合物，以及全氟脂肪族取代的 2-二烷基氨基四氢呋喃和全氟脂肪族取代的 2-二烷基氨基二氢吡喃。