3-Hydroxy-n-(propan-2-yl)propanamide | 7399-84-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Hydroxy-n-(propan-2-yl)propanamide
• 英文别名: 3-hydroxy-N-propan-2-ylpropanamide
• CAS: 7399-84-0
• 化学式: C₆H₁₃NO₂
• mdl: MFCD16827840
• 分子量: 131.17
• InChiKey: GFIMYQPGBOREPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• ANTIPROLIFERATION COMPOUNDS AND USES THEREOF
  申请人：Merck Patent GmbH

  公开号：US20190322658A1

  公开（公告）日：2019-10-24

  The present invention provides compounds of Formula I′, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

  本发明提供了式I′的化合物，或其药学上可接受的盐，以及用于治疗细胞增殖性疾病（例如癌症）的药物组合物和使用方法。
• SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE
  申请人：Xi Ning

  公开号：US20150050239A1

  公开（公告）日：2015-02-19

  The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

  本发明提供了新型取代吡唑酮化合物、药用可接受盐及其制剂，用于调节蛋白酪氨酸激酶活性，以及调节细胞增殖、分化、凋亡、迁移和侵袭等细胞活动。本发明还提供了包含这些化合物的药用可接受组合物以及使用这些组合物治疗哺乳动物，特别是人类的增生性疾病的方法。
• BICYCLIC PYRAZOLONE COMPOUNDS AND METHODS OF USE
  申请人：Xi Ning

  公开号：US20150299219A1

  公开（公告）日：2015-10-22

  The present invention provides substituted bicyclic pyrazolone compounds, which are used to inhibit or modulate the activity of receptor tyrosine kinases, especially Axl, Mer, c-Met and Ron. The invention also provides pharmaceutical compositions comprising the compound disclosed herein, and a method of preventing, treating or lessening the severity of a proliferative disorder in a patient with the compounds or the pharmaceutical compositions disclosed herein.

  本发明提供了取代的双环吡唑酮化合物，用于抑制或调节受体酪氨酸激酶的活性，特别是Axl、Mer、c-Met和Ron。本发明还提供了包含上述化合物的制药组合物，以及使用上述化合物或制药组合物预防、治疗或减轻患者的增殖性疾病的方法。
• Antiproliferation compounds and uses thereof
  申请人：Merck Patent GmbH

  公开号：US10815225B2

  公开（公告）日：2020-10-27

  The present invention provides compounds of Formula I′, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

  本发明提供了式I′化合物或其药学上可接受的盐、其药物组合物及其用于治疗细胞增殖性疾病（如癌症）的方法。
• Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof
  申请人：PharmAkea, Inc.

  公开号：US11072585B2

  公开（公告）日：2021-07-27

  Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.

  本文描述了作为 LOXL2 抑制剂的化合物、制造此类化合物的方法、包含此类化合物的药物组合物和药物，以及使用此类化合物治疗与 LOXL2 活性相关的病症、疾病或失调的方法。