N-(4-溴苯基)-4-(4-氟苯基)-1,3-噻唑-2-胺 | 61383-57-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-溴苯基)-4-(4-氟苯基)-1,3-噻唑-2-胺
• 英文名称: 2-(4-bromophenylamino)-4-(4-fluorophenyl)thiazole
• 英文别名: (4-bromo-phenyl)-[4-(4-fluoro-phenyl)-thiazol-2-yl]-amine；2-(4'-Bromanilino)-4-(4'-fluor-phenyl)thiazol；N-(4-Bromophenyl)-4-(4-fluorophenyl)-2-thiazolamine；N-(4-bromophenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine
• CAS: 61383-57-1
• 化学式: C₁₅H₁₀BrFN₂S
• 分子量: 349.226
• InChiKey: GJCNMVXIUMVYDI-UHFFFAOYSA-N

物化性质

• 熔点：
  131 °C(Solv: ethanol (64-17-5))
• 沸点：
  463.0±55.0 °C(Predicted)
• 密度：
  1.560±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2934100090

反应信息

• 作为产物：
  描述：

  1-(4-溴苯基)-2-硫代脲 、 2-溴-4'-氟苯乙酮 在 ammonium hydroxide 作用下， 以 乙醇 为溶剂， 反应 2.25h， 以92.4%的产率得到N-(4-溴苯基)-4-(4-氟苯基)-1,3-噻唑-2-胺
  参考文献：
  名称：

  Eco-Friendly Synthesis and Insecticidal Activity of Some Fluorinated 2-(N-Arylamino)-4-Arylthiazoles

  摘要：

  A series of fluorinated 2-(N-arylamino)-4-arylthiazoles (3) was synthesized by the condensation of appropriate arylthioureas (2) with corresponding -bromoacetophenones (1) by using ogreen chemistryo techniques, viz. mechanochemical mixing and microwave or ultrasonic irradiation. Compared with conventional procedures, the reaction can be carried out under milder conditions, requiring a shorter reaction time and giving higher yields following the green chemistry methodology. All the synthesized compounds were characterized on the basis of elemental analyses and spectral data (IR, 1H NMR, and mass spectrometry). Representative compounds were also evaluated for their insecticidal activity against Helicoverpa armigera, and some of them showed promising activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

  DOI：

  10.1080/10426500903036014

文献信息

• [EN] GP130 MODULATORS<br/>[FR] MODULATEURS DE GP130
  申请人：UNIV CALIFORNIA

  公开号：WO2018027193A1

  公开（公告）日：2018-02-08

  There are provided, inter alia, compounds and methods useful for the treatment of neurological conditions, such as neurological disorders and neurodegenerative diseases, including Alzheimer's Disease.

  提供了一些化合物和方法，用于治疗神经系统疾病，如神经障碍和神经退行性疾病，包括阿尔茨海默病。
• Compounds and Uses Thereof in Modulating Amyloid Beta
  申请人：Cheng Soan

  公开号：US20070260058A1

  公开（公告）日：2007-11-08

  Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.

  本发明提供了新的化合物、组合物和试剂盒。还提供了调节Aβ水平的方法以及治疗与异常Aβ水平相关的疾病的方法。
• COMPOUNDS AND USES THEREOF IN MODULATING AMYLOID BETA
  申请人：Cheng Soan

  公开号：US20100324032A1

  公开（公告）日：2010-12-23

  Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.

  本发明提供了新型化合物、组合物和试剂盒。还提供了调节Aβ水平的方法和治疗与异常Aβ水平相关的疾病的方法。
• GP130 modulators
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US10947207B2

  公开（公告）日：2021-03-16

  There are provided, inter alia, compounds and methods useful for the treatment of neurological conditions, such as neurological disorders and neurodegenerative diseases, including Alzheimer's Disease.

  除其他外，还提供了用于治疗神经系统疾病（如神经系统紊乱和神经退行性疾病，包括阿尔茨海默病）的化合物和方法。
• GP130 MODULATORS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20190292161A1

  公开（公告）日：2019-09-26

  There are provided, inter alia, compounds and methods useful for the treatment of neurological conditions, such as neurological disorders and neurodegenerative diseases, including Alzheimer's Disease.