1-Pyrenemethyl iodoacetate | 67013-49-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: 1-Pyrenemethyl iodoacetate
• 英文别名: (Pyren-1-yl)methyl iodoacetate；pyren-1-ylmethyl 2-iodoacetate
• CAS: 67013-49-4
• 化学式: C₁₉H₁₃IO₂
• 分子量: 400.216
• InChiKey: NAIAUPRIEVIZPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,11,17,23-tetra-tert-butyl-25,27-di(ethoxycarbonylmethoxy)-26,28-dihydroxycalix[4]arene 、 1-Pyrenemethyl iodoacetate 在 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  A new Na+ sensor based on intramolecular fluorescence energy transfer derived from calix[4]arene

  摘要：

  新合成了一种在低位圈具有芘（作为供体）和苯甲酰氧基（作为受体）基团的杯[4]芳烃，作为基于分子内能量转移的荧光钠离子传感器。

  DOI：

  10.1039/a907457k

文献信息

• A fluorescent calix[4]arene as an intramolecular excimer-forming Na+ sensor in nonaqueous solution
  作者：Takashi Jin、Kazuhiko Ichikawa、Tomiyasu Koyama

  DOI：10.1039/c39920000499

  日期：——

  A new fluorescent calix[4]arene 2 has been synthesized as an intramolecular excimer-forming Na+ sensor which shows a change in fluorescent characteristics specifically upon complexation with Na+.

  一种新的荧光杯[4]芳烃2已被合成为分子内准分子形成Na + 传感器，其特别在与Na + 络合后显示出荧光特性的变化。
• Synthesis and optical resolution of a fluorescent chiral calix[4]arene with two pyrene moieties forming an intramolecular excimer
  作者：Takashi Jin、Takashi Jin、Kenji Monde

  DOI：10.1039/a801995i

  日期：——

  An inherently fluorescent chiral calix[4]arene 2 with two pyrene moieties forming an intramolecular pyrene excimer has been synthesized and optically resolved by an HPLC method using a chiral-packed column.

  我们合成了一种具有固有荧光手性的萼[4]炔 2，其中的两个芘分子形成了分子内的芘准分子，并通过使用手性填料柱的 HPLC 方法进行了光学分辨。
• Hydrophobically-modified protein compositions and methods
  申请人：Pepinsky Blake R.

  公开号：US20050119181A1

  公开（公告）日：2005-06-02

  Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.

  描述了一种水疏性修饰蛋白质及其制备方法。将一种疏水基团附加到蛋白质的表面氨基酸残基上。该疏水基团可以是脂质或肽。或者，可以通过各种化学反应使蛋白质衍生出一个疏水结构。优选的蛋白质是哺乳动物来源的，并从Sonic，Indian和Desert hedgehog组中选择。该疏水基团可用作方便的系链，可附着细胞膜、脂质体或微胶束等载体。
• Methods and compositions for treating disorders involving excitotoxicity
  申请人：Galdes Alphonse

  公开号：US20080221037A1

  公开（公告）日：2008-09-11

  It is shown here that hedgehog polypeptides possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons and other neurons which are sensitive to exotoxicity.

  这里显示出刺猬多肽具有超出表型规范的新颖活性。使用从胚胎第14.5天（E14.5）大鼠腹侧中脑衍生的培养基，我们展示了刺猬对多巴胺能神经元和其他对外毒性敏感的神经元也具有营养作用。
• Synthesis of 1,2-dioxetanes and intermediates therefor
  申请人：TROPIX, INC.

  公开号：EP0582317A2

  公开（公告）日：1994-02-09

  Compounds having formula (I), wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C₁₋₂₀ alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., m-phenylene), produced by reacting a compound having formula (II) with an R-ylating agent (e.g., R₂SO₄) in the presence of an alkali metal alkoxide in a polar aprotic solvent. Also, compounds having formula (III) are produced by reacting a compound having formula (IV) with formula (V), wherein X is an electronegative leaving group (e.g., a halogen anion such as chloride ion) in the presence of a Lewis base (e.g., a trialkyl-amine) dissolved in an aprotic organic solvent (e.g., benzene or toluene). Also, compounds having formula (VI) are produced by reacting a compound of formula (VII) with a tetra-O-acylated-O-hexopyranoside halide, then hydrolysing off the protective acyl groups. The aforementioned compounds and procedures are useful in the synthesis of enzyme-cleavable 1,2-dioxetane ring systems that can serve as members of a binding pair employed, for example, in chemiluminescent immunoassays, DNA probe assays, and direct assays for an enzyme.

  具有式 (I) 的化合物，其中 T 是亚多环烷基（如亚金刚烷-2-基）；R 是 C₁₋₂₀烷基、芳基或环烷基；以及 Y 是荧光发色团（如间苯二酚）、间苯二酚），通过在极性钝化溶剂中，在碱金属烷氧化物存在下，使具有式（II）的化合物与 R-酰化剂（如 R₂SO₄）反应制得。此外，具有式（III）的化合物是通过具有式（IV）的化合物与式（V）反应制得的，其中 X 为电负性离去基团（如卤素阴离子，如氯离子），反应条件为路易斯碱（如三烷基胺）溶于无极性有机溶剂（如苯或甲苯）中。此外，具有式（VI）的化合物是通过式（VII）的化合物与四-O-酰化-O-吡喃己苷卤化物反应，然后水解掉保护酰基而制得的。上述化合物和程序可用于合成可被酶清除的 1，2-二氧杂环烷环系统，这些环系统可作为例如化学发光免疫测定、DNA 探针测定和酶的直接测定中使用的结合对的成员。