4-Hexyl-3-(4-methylphenyl)-1-phenylbenzo[g]isoquinoline | 1262150-80-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-Hexyl-3-(4-methylphenyl)-1-phenylbenzo[g]isoquinoline
• 英文别名: 4-hexyl-3-(4-methylphenyl)-1-phenylbenzo[g]isoquinoline
• CAS: 1262150-80-0
• 化学式: C₃₂H₃₁N
• 分子量: 429.605
• InChiKey: UGANVTRYWSAEGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-[(4-methylphenyl)methyl]benzenecarboximidoyl chloride 、 1-(2-Ethynylphenyl)non-2-ynyl acetate 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 10.0h， 以81%的产率得到4-Hexyl-3-(4-methylphenyl)-1-phenylbenzo[g]isoquinoline
  参考文献：
  名称：

  Synthesis of 2-Azaanthracenes via a Sequential Sonogashira Coupling/Alkynyl Imine−Allenyl Imine Isomerization/Aza-Diels−Alder/Elimination−Aromatization Reaction

  摘要：

  An Interesting sequential Sonogashira coupling/alkynyl imine-allenyl imine isomerization/aza-Diels-Aider/elimination-aromatization reaction, providing a facile synthesis of substituted 2-azaanthracenes from 1,6-dlynes and imidoyl chlorides, is reported. The easy procedure accessing the products efficiently from readily available starting materials may imply a potential synthetic application.

  DOI：

  10.1021/ol1028207

文献信息

• Synthesis of 2-Azaanthracenes via a Sequential Sonogashira Coupling/Alkynyl Imine−Allenyl Imine Isomerization/Aza-Diels−Alder/Elimination−Aromatization Reaction
  作者：Jian Cao、Xiongfa Yang、Xilin Hua、Yuan Deng、Guoqiao Lai

  DOI：10.1021/ol1028207

  日期：2011.2.4

  An Interesting sequential Sonogashira coupling/alkynyl imine-allenyl imine isomerization/aza-Diels-Aider/elimination-aromatization reaction, providing a facile synthesis of substituted 2-azaanthracenes from 1,6-dlynes and imidoyl chlorides, is reported. The easy procedure accessing the products efficiently from readily available starting materials may imply a potential synthetic application.