trimethylphenylphosphonium iodide | 1005-21-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trimethylphenylphosphonium iodide
• 英文别名: Trimethyl-phenyl-phosphonium-iodid；trimethyl(phenyl)phosphanium;iodide
• CAS: 1005-21-6
• 化学式: C₉H₁₄P*I
• 分子量: 280.088
• InChiKey: XQLLUORERPKHEM-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.78
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  trimethylphenylphosphonium iodide 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 Dimethyl-methylene-phenyl-λ⁵-phosphane; compound with GENERIC INORGANIC NEUTRAL COMPONENT
  参考文献：
  名称：

  Endrich, K.; Alburquerque, P.; Korswagen, R. P., Zeitschrift fur Naturforschung, B: Chemical Sciences, 1988, vol. 43, # 10, p. 1293 - 1306

  摘要：

  DOI：
• 作为产物：
  描述：

  苯基膦 在 lithium 作用下， 生成 trimethylphenylphosphonium iodide
  参考文献：
  名称：

  Issleib; Tzschach, Chemische Berichte, 1959, vol. 92, p. 1118,1125

  摘要：

  DOI：
• 作为试剂：
  描述：

  丙烯酸丁酯 、 3Beta-羟基-5-beta-妊娠-20-酮 在 trimethylphenylphosphonium iodide 、 nickel dichloride 、 锌 、 potassium hydroxide 作用下， 以 吡啶 、 水 、 正丁醇 为溶剂， 生成 3-(20-oxo-5β-pregnan-3α-yl)propanoic acid
  参考文献：
  名称：

  Pregnane‐based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss‐of‐function disease‐associated GRIN mutations

  摘要：

  Background and PurposeN‐methyl‐D‐aspartate receptors (NMDARs) play a critical role in synaptic plasticity, and mutations in human genes encoding NMDAR subunits have been described in individuals with various neuropsychiatric disorders. Compounds with a positive allosteric effect are thought to compensate for reduced receptor function.Experimental ApproachWe have used whole‐cell patch‐clamp electrophysiology on recombinant rat NMDARs and human variants found in individuals with neuropsychiatric disorders, in combination with in silico modelling, to explore the site of action of novel epipregnanolone‐based NMDAR modulators.Key ResultsAnalysis of the action of 4‐(20‐oxo‐5β‐pregnan‐3β‐yl) butanoic acid (EPA‐But) at the NMDAR indicates that the effect of this steroid with a “bent” structure is different from that of cholesterol and oxysterols and shares a disuse‐dependent mechanism of NMDAR potentiation with the “planar” steroid 20‐oxo‐pregn‐5‐en‐3β‐yl sulfate (PE‐S). The potentiating effects of EPA‐But and PE‐S are additive. Alanine scan mutagenesis identified residues that reduce the potentiating effect of EPA‐But. No correlation was found between the effects of EPA‐But and PE‐S at mutated receptors that were less sensitive to either steroid. The relative degree of potentiation induced by the two steroids also differed in human NMDARs carrying rare variants of hGluN1 or hGluN2B subunits found in individuals with neuropsychiatric disorders, including intellectual disability, epilepsy, developmental delay, and autism spectrum disorder.Conclusion and ImplicationsOur results show novel sites of action for pregnanolones at the NMDAR and provide an opportunity for the development of new therapeutic neurosteroid‐based ligands to treat diseases associated with glutamatergic system hypofunction.

  DOI：

  10.1111/bph.15841

文献信息

• PROCESSES OF ENANTIOSELECTIVELY FORMING AN AMINOXY COMPOUND AND AN 1,2-OXAZINE COMPOUND
  申请人：Nanyang Technological University

  公开号：US20140228564A1

  公开（公告）日：2014-08-14

  Disclosed is a process of enantioselectively forming an aminoxy compound of Formula (3) In formula (3) R 1 is one of an aliphatic group and an alicyclic group. R 2 is one of hydrogen, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group and an arylalicyclic group. R 3 is one of hydrogen, halogen, hydroxyl, and an aliphatic group with a main chain having 1 to about 10 carbon atoms. The respective aliphatic, alicyclic, aromatic, arylaliphatic or arylalicyclic groups of R 1 , R 2 , and R 3 comprise 0 to about 3 heteroatoms independently selected from the group consisting of N, O, S, Se and Si. The process includes contacting a carbonyl compound of Formula (1) and a nitroso compound of Formula (2) in the presence of a chiral catalyst. The chiral catalyst is a compound of Formula (IX)

  公开了一种对映选择性地形成公式（3）的氨氧化合物的过程。在公式（3）中，R1是脂肪基和脂环基之一。R2是氢，脂肪基，脂环基，芳香基，芳基脂基，芳基环脂基之一。R3是氢，卤素，羟基和具有1至约10个碳原子主链的脂肪基之一。R1，R2和R3的各自脂肪，脂环，芳香，芳基脂基或芳基环脂基包括0至约3个独立选择的异原子，所述异原子选自N，O，S，Se和Si的群。该过程包括在手性催化剂的存在下接触公式（1）的羰基化合物和公式（2）的亚硝基化合物。手性催化剂是公式（IX）的化合物。
• Formation of a cationic alkylidene complex via formal hydride abstraction: synthesis and structural characterization of [W(PMe3)4(η2-CHPMe2)H]X (X = Br, I)
  作者：Aaron Sattler、Gerard Parkin

  DOI：10.1039/c1cc15457e

  日期：——

  W(PMe(3))(4)(eta(2)-CH(2)PMe(2))H reacts with aryl halides to give the alkylidene complex, [W(PMe(3))(4)(eta(2)-CHPMe(2))H](+), which reacts with LiAlD(4) to give selectively W(PMe(3))(4)(eta(2)-CHDPMe(2))H, in which the deuterium resides in the methylene group; subsequent migration of deuterium from the methylene group provides a means to measure the rate constant for the formation of the 16-electron

  W（PMe（3））（4）（eta（2）-CH（2）PMe（2））H与芳基卤反应生成亚烷基络合物[W（PMe（3））（4）（eta（ 2）-CHPMe（2））H]（+），它与LiAlD（4）反应以选择性地产生W（PMe（3））（4）（eta（2）-CHDPMe（2））H，其中氘位于亚甲基中；氘从亚甲基的后续迁移提供了一种手段，用于测量从W（PMe（3））（4）（eta）形成16电子物种[W（PMe（3））（5）]的速率常数（2）-CH（2）PMe（2））H。
• Process for producing an aliphatic isocyanate
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0161550A1

  公开（公告）日：1985-11-21

  A process for producing an aliphatic isocyanate from an aliphatic primary amine comprising a carbonylation step in which an aliphatic primary amine is allowed to react with carbon monoxide at a temperature of about 100-250°C in the presence of an aromatic hydroxyl compound having a pKa value of not more than about 11, molecular oxigen and a catalyst system comprising at least one member selected from palladium and rhodium metals and components thereof and at least one member selected from iodine and bromine and compounds thereof and a combined separation and recovery step comprising a pyrolysis-distillation reaction in which the mixture of carbonylated products is heated to a temperature of from about 100 to 300°C.

  一种用脂肪族伯胺生产脂肪族异氰酸酯的工艺，包括一个羰基化步骤，在该步骤中，脂肪族伯胺在 pKa 值不大于约 11 的芳香族羟基化合物、分子氧化物和催化剂体系的存在下，在约 100-250°C 的温度下与一氧化碳反应，该催化剂体系包括至少一种选自钯和铑金属及其组分的成员和至少一种选自碘和溴及其化合物的成员，以及一个分离和回收组合步骤，该步骤包括热解-蒸馏反应，在该反应中，羰基化产物混合物被加热到约 100 至 300°C 的温度。
• Anti-microbial polymer incorporating a quaternary ammonium group
  申请人：CHEMGREEN INNOVATION INC.

  公开号：US10993437B2

  公开（公告）日：2021-05-04

  The present disclosure relates to antimicrobial polymers which impart prolonged antimicrobial activity to a surface or in a solution, the polymers comprising as repeating monomers a polymerizable cyclic moiety forming part of the polymer backbone and an anti-microbial moiety such as a quaternary ammonium moiety in the side chain. The polymer may further comprise polymerizable units of at least one unsaturated monomer having an ethylenically unsaturated double or triple bond.

  本公开涉及在表面或溶液中赋予长期抗菌活性的抗菌聚合物，这种聚合物包括作为 重复单体的可聚合环状分子（构成聚合物骨架的一部分）和抗微生物分子（如侧链中的 季铵分子）。聚合物可进一步包括至少一种具有乙烯不饱和双键或三键的不饱和单体的可聚合单元。
• Michaelis, Justus Liebigs Annalen der Chemie, 1876, vol. 181, p. 322
  作者：Michaelis

  DOI：——

  日期：——