1-Butyramido-hexadecan | 94677-71-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-Butyramido-hexadecan
• 英文别名: N-hexadecylbutanamide
• CAS: 94677-71-1
• 化学式: C₂₀H₄₁NO
• 分子量: 311.552
• InChiKey: XXGBVUBHLLDJQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Butyramido-hexadecan 生成 15-Hydroxy-1-butyramido-hexadecan
  参考文献：
  名称：

  长链脂族化合物的微生物氧化。第四部分 具有极性末端基团的烷烃衍生物

  摘要：

  在含有葡萄糖的培养基中，鹅掌To影响具有以下基团作为末端取代基的长链烷烃衍生物的ω-和ω-1-羟基化：–NO 2，–O·SO 2 ·CH 3，–NH·SO 2 · CH 3，–NH·CO·CH 3，–NH·CO·C 3 H 7，–NH·CO·C 4 H 9，–NH·CO 2 ·C 2 H 5，–CO·NH·CH 3， –CO·N（CH 3）2，–CN和–CO·CH 3。提出这些羟基化是由通常催化脂肪酸的ω-和ω-1-羟基化的酶催化的。酵母还将7-（己基氨基羰基氧基）庚烷转化为7-（己基氨基羰基氧基）庚酸，并转化为掺入7-（6-羟基己基氨基羰基氧基）庚酸的糖脂。

  DOI：

  10.1039/j39680002821
• 作为产物：
  描述：

  丁酸酐 、 十六胺 生成 1-Butyramido-hexadecan
  参考文献：
  名称：

  长链脂族化合物的微生物氧化。第四部分 具有极性末端基团的烷烃衍生物

  摘要：

  在含有葡萄糖的培养基中，鹅掌To影响具有以下基团作为末端取代基的长链烷烃衍生物的ω-和ω-1-羟基化：–NO 2，–O·SO 2 ·CH 3，–NH·SO 2 · CH 3，–NH·CO·CH 3，–NH·CO·C 3 H 7，–NH·CO·C 4 H 9，–NH·CO 2 ·C 2 H 5，–CO·NH·CH 3， –CO·N（CH 3）2，–CN和–CO·CH 3。提出这些羟基化是由通常催化脂肪酸的ω-和ω-1-羟基化的酶催化的。酵母还将7-（己基氨基羰基氧基）庚烷转化为7-（己基氨基羰基氧基）庚酸，并转化为掺入7-（6-羟基己基氨基羰基氧基）庚酸的糖脂。

  DOI：

  10.1039/j39680002821

文献信息

• Amine-containing lipids and uses thereof
  申请人：Anderson Daniel G.

  公开号：US20110009641A1

  公开（公告）日：2011-01-13

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
• THERAPEUTIC COMPOSITIONS
  申请人：Tzianabos Arthur

  公开号：US20110052673A1

  公开（公告）日：2011-03-03

  Therapeutic compositions containing therapeutic agents and nitrogen-containing lipids are described. These tertiary amine-containing polymers are preferably biodegradable and biocompatible. Nanoparticles, microparticles, and complexes containing lipid/therapeutic agent complexes are also described.
• MODULATION OF THE IMMUNE RESPONSE
  申请人：Nguyen David-Huy Nhu

  公开号：US20120009222A1

  公开（公告）日：2012-01-12

  The present invention provides lipidoids that can be used to modulate the immune response in a subject. Lipidoids are prepared by the conjugate addition of an amine to an acrylate to acrylamide. The lipidoids form complexes or particles with an immunostimulatory polynucleotide, which are then administerd to a subject. Such compositions have been found to stimulate the production of cytokines and increase both humoral and cell-mediate immune response. The invention also provides pharmaceuti-cal compositions thereof and methods for using the same.
• AMINE-CONTAINING LIPIDS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20160009657A1

  公开（公告）日：2016-01-14

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
• US9006487B2
  申请人：——

  公开号：US9006487B2

  公开（公告）日：2015-04-14