N-(4-甲氧基苯基)-氯亚膦酰胺酸 2-氯苯基酯 | 82556-11-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-甲氧基苯基)-氯亚膦酰胺酸 2-氯苯基酯
• 中文别名: 5-[(二甲氨基)甲基]-1,2,5-三甲基-4-苯基哌啶-4-基丙酸酯二盐酸；N-(4-甲氧基苯基)-氯亚膦酰胺酸2-氯苯基酯
• 英文名称: o-chlorophenyl p-anisidophosphorochloridate
• 英文别名: Cppac；N-[chloro-(2-chlorophenoxy)phosphoryl]-4-methoxyaniline
• CAS: 82556-11-4
• 化学式: C₁₃H₁₂Cl₂NO₃P
• 分子量: 332.123
• InChiKey: KCDQVKCQPQPGHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(4-甲氧基苯基)-氯亚膦酰胺酸 2-氯苯基酯 在 zinc dibromide 作用下， 生成 2'-O-tetrahydrofuranyl-3'-(o-chlorophenyl)-p-anisidophosphoryl-N-benzoylcytidine
  参考文献：
  名称：

  Iwai, Shigenori; Asaka, Miyuki; Inoue, Hideo, Chemical and pharmaceutical bulletin, 1985, vol. 33, # 10, p. 4618 - 4620

  摘要：

  DOI：

文献信息

• A new synthetic method for 5'-triphosphoryl-adenylyl-(2'-5')-adenylyl-(2'-5')-adenosine (2-5A) and 2-5A core using 3'-O-tetrahydrofuranyl-adenosine derivatives.
  作者：Eiko Ohtsuka、Akio Yamane、Morio Ikehara

  DOI：10.1248/cpb.30.376

  日期：——

  2' or 3'-O-Tetrahydrofuranyl derivatives of ribonucleosides have been synthesized by treating 2, 3-dihydrofurane with bis tert-butyldi-methylsilyl N-protected nucleosides. Using 3'-O-tetrahydrofuranyl-N-benzoyladenosine as the starting meterial 5'-phosphoryladenylyl-(2'-5')-adenylyl-(2'-5')-adenosine was synthesized in a good yield and converted to the triphosphoryl derivative (2-5A). The 2'-5' linked triadenylate (2-5A core) was also prepared by the same phosphotriester method.

  通过将2,3-二氢呋喃与双叔丁基二甲基硅烷保护的N-保护核苷反应，合成了2'或3'-O-四氢呋喃基核苷衍生物。以3'-O-四氢呋喃基-N-苯甲酰腺苷为起始物质，高产率地合成了5'-磷酸腺苷酰-(2'-5')-腺苷酰-(2'-5')-腺苷，并将其转化为三磷酸衍生物（2-5A）。通过相同的磷酸三酯法，也制备了2'-5'连接的三腺苷酸（2-5A核心）。
• Studies on transfer ribonucleic acids and related compounds. XLIV. A large-scale synthesis of the anticodon heptanucleotide of formyl-methionine transfer ribonucleic acid by using 2'-O-tetrahydrofuranylnucleosides.
  作者：EIKO OHTSUKA、MITSURU OHKUBO、AKIO YAMANE、MORIO IKEHARA

  DOI：10.1248/cpb.31.1910

  日期：——

  2'-O-Tetrahydrofuranyl nucleosides were prepared by an improved procedure via 3', 5'-tetraisopropyldisiloxanylnucleosides. A large scale synthesis of the anticodon heptanucleotide C-U-C-A-U-A-A of E. coli formylmethionine tRNA was performed by the phosphotriester method involving condensation of oligonucleotides having 2'-O-tetrahydrofuranyl protecting groups.

  通过改进的3',5'-四异丙基二硅氧烷基核苷路线，制备了2'-O-四氢呋喃基核苷。采用磷酰三酯法，涉及具有2'-O-四氢呋喃保护基团的寡核苷酸的缩合反应，进行了大肠杆菌甲酰甲硫氨酰tRNA的反密码子七核苷酸C-U-C-A-U-A-A的大规模合成。
• Ohtsuka, Eiko; Taniyama, Yoshio; iWai, Shigenori, Chemical and pharmaceutical bulletin, 1984, vol. 32, # 1, p. 85 - 93
  作者：Ohtsuka, Eiko、Taniyama, Yoshio、iWai, Shigenori、Yoshida, Tadao、Ikehara, Morio

  DOI：——

  日期：——
• Ohtsuka, Eiko; Yamane, Akio; Ikehara, Morio, Chemical and pharmaceutical bulletin, 1983, vol. 31, # 5, p. 1534 - 1543
  作者：Ohtsuka, Eiko、Yamane, Akio、Ikehara, Morio

  DOI：——

  日期：——