3-hydroxy-N-(4-fluorophenyl)propanamide | 38470-23-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-hydroxy-N-(4-fluorophenyl)propanamide
• 英文别名: N-(4-Fluorphenyl)-3-hydroxypropionsaeureamid；N-(4-fluorophenyl)-3-hydroxypropanamide
• CAS: 38470-23-4
• 化学式: C₉H₁₀FNO₂
• 分子量: 183.182
• InChiKey: XOWFOLVHFIJRHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 3-hydroxy-N-(4-fluorophenyl)propanamide 以53%的产率得到
  参考文献：
  名称：

  KAMETANI, TETSUJI;KIGASAWA, KAZUO;HIIRAGI, MINEHARU;WAGATSUMA, NAGATOSHI;+, J. PHARM. SOC. JAP., 1981, 101, N 4, 336-344

  摘要：

  DOI：
• 作为产物：
  描述：

  N-环丙基-4-氟苯胺 在 air 作用下， 反应 66.0h， 以40%的产率得到3-hydroxy-N-(4-fluorophenyl)propanamide
  参考文献：
  名称：

  Air Oxidation of N-Cyclopropylanilines

  摘要：

  Air oxidation of N-cyclopropylanilines was shown to occur under either ambient conditions or accelerated conditions (warming or shining light) in an open container. A subsequent fragmentation resulted in formation of the corresponding acetamide. While potential mechanisms have been previously proposed, simple aerobic oxidation to beta-hydroxy-propionamides in the absence of a radical promoter has not been previously reported.

  DOI：

  10.1080/00397911.2010.545166

文献信息

• CATALYST FOR CONVERTING ESTER TO AMIDE USING HYDROXYL GROUP AS ORIENTATION GROUP
  申请人：CHUBU UNIVERSITY EDUCATIONAL FOUNDATION

  公开号：US20210070690A1

  公开（公告）日：2021-03-11

  Provided is a method for amidating a hydroxy ester compound at a high chemical selectivity. The amidation reaction method for a hydroxy ester compound comprises, in the presence of a catalyst containing a compound of a transition metal of the group 4 or group 5 in the periodic table, reacting at least one kind of hydroxy ester compound selected from the group consisting of an α-hydroxy ester compound, a β-hydroxy ester compound, a γ-hydroxy ester compound and a δ-hydroxy ester compound with an amino compound so as to amidate an ester group having a hydroxyl group at the α-, β-, γ- or δ-position of the hydroxy ester compound.

  提供了一种在高化学选择��下对羟基酯化合物进行酰胺化的方法。对羟基酯化合物进行酰胺化反应的方法包括，在含有周期表中第4组或第5组过渡金属化合物的催化剂存在下，将从α-羟基酯化合物、β-羟基酯化合物、γ-羟基酯化合物和δ-羟基酯化合物组成的羟基酯化合物中选择的至少一种羟基酯化合物与氨基化合物反应，以酰胺化具有α-、β-、γ-或δ-位置的羟基酯化合物中的羟基基团。
• COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：Idenix Pharmaceuticals LLC

  公开号：EP2755985B1

  公开（公告）日：2017-11-01
• [EN] COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS<br/>[FR] COMPOSÉS ET COMPOSITIONS PHARMACEUTIQUES POUR LE TRAITEMENT D'INFECTIONS VIRALES
  申请人：IDENIX PHARMACEUTICALS INC

  公开号：WO2013039855A1

  公开（公告）日：2013-03-21

  Provided herein are compounds, compositions and methods for the treatment of liver disorders, including HCV infections. In one embodiment, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
• Air Oxidation of <i>N</i>-Cyclopropylanilines
  作者：Anthony Blackburn、Daniel M. Bowles、Timothy T. Curran、Hui Kim

  DOI：10.1080/00397911.2010.545166

  日期：2012.6.15

  Air oxidation of N-cyclopropylanilines was shown to occur under either ambient conditions or accelerated conditions (warming or shining light) in an open container. A subsequent fragmentation resulted in formation of the corresponding acetamide. While potential mechanisms have been previously proposed, simple aerobic oxidation to beta-hydroxy-propionamides in the absence of a radical promoter has not been previously reported.
• KAMETANI, TETSUJI;KIGASAWA, KAZUO;HIIRAGI, MINEHARU;WAGATSUMA, NAGATOSHI;+, J. PHARM. SOC. JAP., 1981, 101, N 4, 336-344
  作者：KAMETANI, TETSUJI、KIGASAWA, KAZUO、HIIRAGI, MINEHARU、WAGATSUMA, NAGATOSHI、+

  DOI：——

  日期：——