nitrooxyethyl L-valinate | 1217693-72-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: nitrooxyethyl L-valinate
• 英文别名: 2'-nitrooxyethyl 2-amino-3-methylbutanoate；2-nitrooxyethyl (2S)-2-amino-3-methylbutanoate
• CAS: 1217693-72-5
• 化学式: C₇H₁₄N₂O₅
• 分子量: 206.199
• InChiKey: IKCDUFWXQFHRRU-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  nitrooxyethyl boc-valinate 在 盐酸 、 水 、 sodium hydroxide 作用下， 以 乙酸乙酯 、 水 为溶剂， 反应 10.0h， 生成 nitrooxyethyl L-valinate
  参考文献：
  名称：

  [EN] NITRIC OXIDE RELEASING AMINO ACID ESTER COMPOUND, COMPOSITION AND METHOD OF USE
  [FR] COMPOSÉ D'ESTER D'ACIDE AMINÉ LIBÉRANT UN OXYDE NITRIQUE, COMPOSITION ET  PROCÉDÉ D'UTILISATION

  摘要：

  提供的氨基酸酯化合物包括至少一个释放一氧化氮基团的化合物，其药学上可接受的盐和组合物。这些化合物涉及氨基酸侧链或其衍生物以及释放一氧化氮基团，如下面的结构所示：其中R1是乙基或氨基酸侧链基团或其衍生物，R2是氨基酸侧链基团或其衍生物，n是从1到10的整数。

  公开号：

  WO2010034118A1

文献信息

• NITRIC OXIDE AMINO ACID ESTER COMPOUND, COMPOSITIONS FOR INCREASING NITRIC OXIDE LEVELS AND METHOD OF USE
  申请人：Farber Michael

  公开号：US20100076043A1

  公开（公告）日：2010-03-25

  There is provided novel amino acid ester compounds comprising at least one nitric oxide releasing group and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one amino acid ester compound comprising at least one nitric oxide releasing group, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. Also provided are compositions for increasing nitric oxide physiological levels in a subject, methods for increasing nitric oxide physiological levels in a subject, methods for improving a subject's muscle strength, athletic performances and/or lean body mass gain and or performance in a subject.

  提供了包含至少一个释放一氧化氮基团的新型氨基酸酯化合物及其药用可接受盐，以及包含至少一个含有至少一个释放一氧化氮基团的氨基酸酯化合物的新型组合物，还可包括至少一个一氧化氮供体和/或至少一个治疗剂。还提供了用于增加受试者体内一氧化氮生理水平的组合物，用于增加受试者体内一氧化氮生理水平的方法，用于改善受试者肌肉力量、运动表现和/或瘦体重增加以及/或受试者表现的方法。
• NITRIC OXIDE RELEASING AMINO ACID ESTER COMPOUND, COMPOSITION AND METHOD OF USE
  申请人：Farber Michael

  公开号：US20110195935A1

  公开（公告）日：2011-08-11

  There is provided amino acid ester compounds comprising at least one nitric oxide releasing group, pharmaceutically acceptable salts thereof and compositions thereof. These compounds involve an amino acid side-chain or an amino acid derivative thereof and a nitric oxide releasing group as depicted in the following structures: wherein R 1 is either an ethyl or an amino acid side-chain group or an amino acid derivative thereof and R 2 is an amino acid side-chain group or an amino acid derivative thereof and n is an integer from 1 to 10.

  提供了一种氨基酸酯化合物，其中包含至少一个释放一氧化氮基团的化合物，其药学上可接受的盐和组成物。这些化合物涉及氨基酸侧链或其衍生物和释放一氧化氮基团，如下图所示：其中R1是乙基或氨基酸侧链基团或其衍生物，R2是氨基酸侧链基团或其衍生物，n是1到10的整数。
• Nitric oxide amino acid ester compound, composition for increasing nitirc oxide levels and method of use
  申请人：Farber Michael

  公开号：US20100311780A1

  公开（公告）日：2010-12-09

  There is provided novel amino acid ester compounds comprising at least one nitric oxide releasing group and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one amino acid ester compound comprising at least one nitric oxide releasing group, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. Also provided are compositions for increasing nitric oxide physiological levels in a subject, methods for increasing nitric oxide physiological levels in a subject, methods for improving a subject's muscle strength, athletic performances and/or lean body mass gain and or performance in a subject.

  本发明提供了一种新型氨基酸酯化合物，其中包括至少一个释放一氧化氮的基团和其药学上可接受的盐，并提供了至少包括一种氨基酸酯化合物的新型组合物，其中包括至少一个释放一氧化氮的基团，以及可选地，至少一种一氧化氮供体和/或至少一种治疗剂。此外，还提供了用于增加受试者体内一氧化氮生理水平的组合物，以及用于增加受试者体内一氧化氮生理水平、改善受试者肌肉力量、运动表现和/或瘦体重增加以及受试者表现的方法。
• NITRIC OXIDE AMINO ACID ESTERS FOR IMPROVING VASCULAR CIRCULATION, AND PROPHYLAXIS OR TREATMENT OF A CONDITION ASSOCIATED WITH IMPAIRED BLOOD CIRCULATION
  申请人：Oral Delivery Technology Ltd.

  公开号：EP2632453A1

  公开（公告）日：2013-09-04
• NITRIC OXIDE AMINO ACID ESTERS FOR THE TREATMENT OF CHRONIC PAIN
  申请人：FARBER Michael

  公开号：US20120289597A1

  公开（公告）日：2012-11-15

  There is provided a topical composition and a method for treating or alleviating pain in a patient in need thereof. The topical composition contain amino acid ester compounds comprising at least one nitric oxide releasing group and pharmaceutical salts thereof and a topical analgesic compound.