methyl 4-phthalimidocyclohexanecarboxylate | 709638-17-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: methyl 4-phthalimidocyclohexanecarboxylate
• 英文别名: Methyl 4-(1,3-dioxoisoindol-2-yl)cyclohexane-1-carboxylate
• CAS: 709638-17-5
• 化学式: C₁₆H₁₇NO₄
• 分子量: 287.315
• InChiKey: DEVSUVIKFSBVFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 4-phthalimidocyclohexanecarboxylate 、 异丙醇 在 potassium tert-butylate 、 溶剂黄146 作用下， 反应 30.0h， 以70.64%的产率得到isopropyl trans-4-phthalimidocyclohexanecarboxylate
  参考文献：
  名称：

  Short and Efficient Process for the Synthesis of trans-4-Aminocyclohexanecarboxylic Acid Derivatives

  摘要：

  This contribution relates to an industrially feasible process for the preparation of isomerically pure trans-4-amino-1-cyclohexanecarboxylic acid derivatives that are useful building blocks in the synthesis of several pharmacologically active compounds such as glimepiride, L-370518.

  DOI：

  10.1021/op900195w
• 作为产物：
  描述：

  苯酐 、 4-氨基环己甲酸甲酯盐酸盐 在 三乙胺 作用下， 以 甲苯 为溶剂， 以75%的产率得到methyl 4-phthalimidocyclohexanecarboxylate
  参考文献：
  名称：

  Short and Efficient Process for the Synthesis of trans-4-Aminocyclohexanecarboxylic Acid Derivatives

  摘要：

  This contribution relates to an industrially feasible process for the preparation of isomerically pure trans-4-amino-1-cyclohexanecarboxylic acid derivatives that are useful building blocks in the synthesis of several pharmacologically active compounds such as glimepiride, L-370518.

  DOI：

  10.1021/op900195w

文献信息

• Short and Efficient Process for the Synthesis of <i>trans-</i>4-Aminocyclohexanecarboxylic Acid Derivatives
  作者：Pankaj S. Patil、Ulhas S. Mahajan、Swapnil P. Sonawane、Mukund K. Gurjar

  DOI：10.1021/op900195w

  日期：2009.11.20

  This contribution relates to an industrially feasible process for the preparation of isomerically pure trans-4-amino-1-cyclohexanecarboxylic acid derivatives that are useful building blocks in the synthesis of several pharmacologically active compounds such as glimepiride, L-370518.