4-chloro-N-[2-(4-chlorobutanoylamino)ethyl]butanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-chloro-N-[2-(4-chlorobutanoylamino)ethyl]butanamide
• 化学式: C₁₀H₁₈Cl₂N₂O₂
• 分子量: 269.17
• InChiKey: PABTXNPPNQVJSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Biodegradable polyionenes
  申请人：AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

  公开号：US11198761B2

  公开（公告）日：2021-12-14

  Synthesis of polyionenes with built-in degradable linkers through addition polymerization of a novel class of degradable A2-type monomers (d-A2), and their use as antimicrobial agents are disclosed. A library of biodegradable polyionenes and Gemini-surfactants made from d-A2 monomers are also disclosed. These materials have potent and broad spectrum of antimicrobial activity with high selectivity over mammalian cells.

  本研究公开了通过对一类新型可降解 A2 型单体（d-A2）进行加成聚合，合成具有内置可降解连接体的聚阴离子，并将其用作抗菌剂。此外，还公开了一个由 d-A2 单体制成的可生物降解的聚阴离子和双子表面活性剂库。这些材料具有强效、广谱的抗菌活性，对哺乳动物细胞具有高选择性。
• BIODEGRADABLE POLYIONENES
  申请人：AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

  公开号：US20200040136A1

  公开（公告）日：2020-02-06

  Synthesis of polyionenes with built-in degradable linkers through addition polymerization of a novel class of degradable A 2 -type monomers (d-A 2 ), and their use as antimicrobial agents are disclosed. A library of biodegradable polyionenes and Gemini-surfactants made from d-A 2 monomers are also disclosed. These materials have potent and broad spectrum of antimicrobial activity with high selectivity over mammalian cells.