N-(2-morpholino-ethyl)-valeramide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(2-morpholino-ethyl)-valeramide
• 英文别名: N-(2-Morpholino-aethyl)-valeramid；N-(2-morpholin-4-ylethyl)pentanamide
• 化学式: C₁₁H₂₂N₂O₂
• mdl: MFCD03384227
• 分子量: 214.308
• InChiKey: WHIMLDBJPDWPFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.909
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] METHODS AND COMPOUNDS FOR TREATING ALCOHOL USE DISORDERS AND ASSOCIATED DISEASES<br/>[FR] PROCÉDÉS ET COMPOSÉS POUR LE TRAITEMENT DE TROUBLES D'UTILISATION D'ALCOOL ET DE MALADIES ASSOCIÉES
  申请人：PHARMATROPHIX INC

  公开号：WO2018039641A1

  公开（公告）日：2018-03-01

  Methods and compounds for treating alcohol use disorder and associated diseases. Included is the administering to a subject in need there of an effective amount of a compound having a modulating effect on p75NTR.

  治疗酒精使用障碍和相关疾病的方法和化合物。包括向需要的受试者施用对p75NTR具有调节作用的化合物的有效量。
• [EN] AMINO LIPIDS, THEIR SYNTHESIS AND USES THEREOF<br/>[FR] LIPIDES AMINÉS, LEUR SYNTHÈSE ET LEURS UTILISATIONS
  申请人：KARLSRUHER INST TECHNOLOGIE

  公开号：WO2012167869A1

  公开（公告）日：2012-12-13

  The present invention provides new amino lipids and a convenient method for synthesising these compounds. These (cationic) amino lipids have good properties as transfection agents. The method is an economic versatile two step synthesis allowing the preparation of various amino lipids thus leading to the assembly of a combinatorial library of transfection agents. Moreover, the present invention provides lipid particles (liposomes) containing said amino lipids and their use for delivering bioactive agents into cells. The invention encompasses also the use of lipid particles containing the cationic amino lipids as medicament.

  本发明提供了新的氨基脂质和一种方便的合成这些化合物的方法。这些（阳离子）氨基脂质作为转染剂具有良好的性能。该方法是一种经济多功能的两步合成方法，允许制备各种氨基脂质，从而导致转染剂组合库的组装。此外，本发明提供了含有上述氨基脂质的脂质粒子（脂质体）及其用于将生物活性剂输送到细胞中的用途。该发明还包括含有阳离子氨基脂质的脂质粒子作为药物的用途。
• Aryl cyclopropyl-amino-isoquinolinyl amide compounds
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：US10858339B2

  公开（公告）日：2020-12-08

  Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the disclosure are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, diseases characterized by abnormal growth, such as cancers, and inflammatory diseases. The disclosure further provides compositions containing isoquinoline amide compounds.

  本文提供的是芳基环丙基氨基异喹啉酰胺化合物。特别是，本公开提供的化合物可影响细胞中激酶的功能，并可作为治疗剂或与治疗剂一起使用。本公开的化合物可用于治疗多种疾病和病症，包括眼部疾病（如青光眼）、心血管疾病、以异常生长为特征的疾病（如癌症）以及炎症性疾病。本公开进一步提供了含有异喹啉酰胺化合物的组合物。
• NEUROTROPHIN MIMETICS AND USES THEREOF
  申请人：The University of North Carolina At Chapel Hill

  公开号：EP2403839A2

  公开（公告）日：2012-01-11
• CRYSTALLINE FORMS OF NEUROTROPHIN MIMETIC COMPOUNDS AND THEIR SALTS
  申请人：Pharmatrophix Inc.

  公开号：EP2498782A1

  公开（公告）日：2012-09-19