10-Hydrazinyl-10-oxodecanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 10-Hydrazinyl-10-oxodecanoic acid
• 化学式: C₁₀H₂₀N₂O₃
• mdl: MFCD01893303
• 分子量: 216.28
• InChiKey: XRNSUHLEVOUTDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Solubilization and Targeted Delivery of Drugs With Self-Assembling Amphiphilic Polymers
  申请人：Diwan Anil

  公开号：US20100260743A1

  公开（公告）日：2010-10-14

  There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds such as drugs, vitamins, dyes, and imaging agents. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties useful for the targeted delivery of drugs and imaging agents.

  提供的两性可降解共聚物包括具有羟基亲水骨架和作为疏水组分的脂肪族侧链的共聚物。这些聚合物在水性环境中形成纳米级分子聚集体，具有疏水内部，能够溶解不溶于水的有机化合物，如药物、维生素、染料和成像剂。这些聚合物可选择性地具有反应性功能基团，提供与抗体、配体和其他靶向基团的结合点，有助于药物和成像剂的靶向传递。
• Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them
  申请人：Platzek Johannes

  公开号：US20050118105A1

  公开（公告）日：2005-06-02

  Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.

  级联聚合物，含有复合配体，可选含有至少五个原子序数为21-29、39、42、44或57-83的元素离子，如果需要，还可以含有无机和/或有机碱、氨基酸或氨基酸酰胺阳离子，是用于诊断和治疗的有价值的络合物化合物和络合物。
• Cascade polymer bound complexing compounds, their complexes and conjugates, process for their production, and pharmaceutical agents containing them
  申请人：Schering AG

  公开号：US20020068037A1

  公开（公告）日：2002-06-06

  Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.

  级联聚合物，含有复杂结合配体，可选含有原子序数为21-29、39、42、44或57-83的至少五个元素离子，以及如有需要，无机和/或有机碱、氨基酸或氨基酸酰胺的阳离子，是用于诊断和治疗的有价值的络合化合物和络合物。
• SELF ASSEMBLING AMPHIPHILIC POLYMERS AS ANTIVIRAL AGENTS
  申请人：Diwan Anil

  公开号：US20100008938A1

  公开（公告）日：2010-01-14

  There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds and disrupting viral coat proteins. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties which mediate adherence of the aggregate to a viral target.

  提供的两性亲水可生物降解共聚物包括具有侧链脂肪族基作为疏水成分的亲水性骨架。这些聚合物在水性环境中形成纳米级分子聚集体，具有疏水内部，能够溶解不溶性有机化合物并破坏病毒外壳蛋白。这些聚合物可选择性地具有反应性功能基团，提供抗体、配基和其他靶向基团的附着点，介导聚集体与病毒靶标的粘附。
• SELF-ASSEMBLING AMPHIPHILIC POLYMERS AS ANTI-CANCER AGENTS
  申请人：Diwan Anil R.

  公开号：US20100239659A1

  公开（公告）日：2010-09-23

  The invention provides amphiphilic biocompatible copolymers which have a hydrophilic backbone and pendant hydrophobic groups. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors within which anticancer drugs may be solubilized. The polymers optionally feature attached antibodies, receptor ligands, and other targeting moieties which mediate adherence of the drug-carrying aggregates to targeted cancer cells.

  本发明提供了一种两性亲水的生物相容性共聚物，其具有亲水性骨架和挂链疏水基团。这些聚合物在水性环境中形成纳米级分子聚集体，其中具有疏水性内部，可在其中溶解抗癌药物。这些聚合物可选地具有连接的抗体、受体配体和其他靶向基团，这些基团介导药物携带聚集体与靶向癌细胞的附着。