adamantan | 52944-09-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: adamantan
• 英文别名: N-Adamantan-1-yl-2-phenoxy-acetamide；N-(1-adamantyl)-2-phenoxyacetamide
• CAS: 52944-09-9
• 化学式: C₁₈H₂₃NO₂
• 分子量: 285.386
• InChiKey: OZKAFRPZFRYKJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• ADAMANTYL DERIVATIVES AS INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME
  申请人：Abbott Laboratories

  公开号：EP1846363B1

  公开（公告）日：2012-04-25
• Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
  申请人：AbbVie Inc.

  公开号：EP2269977B1

  公开（公告）日：2016-04-27
• N-2 Adamantanyl-2-Phenoxy-Acetamide Derivatives as 11-Beta Hydroxysteroid Dehydrogenase Inhibitors
  申请人：Jaroskova Libuse

  公开号：US20080064693A1

  公开（公告）日：2008-03-13

  The N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 1, 2, 3, or 4; Z represents O, S, NR 6 , SO or SO 2 ; R 1 represent hydrogen, cyano, hydroxy, or C 1-4 alkyl optionally substituted with halo, R 2 represents hydrogen, C 1-4 alkyl, or C 1-4 alkyloxy-; R 3 represents hydrogen, C 1-4 alkyl, C 1-4 alkyloxy- or R 3 combined with R 2 form together a divalent radical selected from the group consisting of —O—CH 2 — (a), —NR 7 —CH 2 — (b), —(CR 8 R 9 ) m — (c) and —CR 10 ═ (d) wherein m represents 1 or 2 and R 7 , R 8 , R 9 and R 10 are each independently selected from hydrogen or C 1-4 alkyl; R 4 represents hydrogen, halo, hydroxy, cyano, amino, NR 11 R 12 , C 1-4 alkyloxy-optionally substituted with one or where possible two or three substituents selected from hydroxy and halo or R 4 represents C 1-4 alkyl optionally substituted with one or where possible two or three substituents selected from hydroxy and halo; R 5 represents hydrogen, halo, cyano, amino, phenyl, hydroxy, C 1-4 alkyloxycarbonyl, hydroxycarbonyl, NR 13 R 14 or C 1-4 alkyl substituted with one or more substituents selected from hydroxycarbonyl, phenyl, C 1-4 alkyloxy or NR 15 R 16 ; R 6 represents hydrogen; R 11 and R 12 each independently represent hydrogen, C 1-4 alkyl or C 1-4 alkylcarbonyl-; R 13 and R 14 each independently represent hydrogen, C 1-4 alkyl or C 1-4 alkylcarbonyl-; R 15 and R 16 each independently represent hydrogen, C 1-4 alkyl or C 1-4 alkylcarbonyl-; R 17 and R 18 each independently represent hydrogen, C 1-4 alkyl or C 1-4 alkylcarbonyl-.
• US8344181B2
  申请人：——

  公开号：US8344181B2

  公开（公告）日：2013-01-01