Oxydiethane-2,1-diyl bis[(2-hydroxyethyl)carbamate] | 6311-12-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Oxydiethane-2,1-diyl bis[(2-hydroxyethyl)carbamate]
• 英文别名: 2-[2-(2-hydroxyethylcarbamoyloxy)ethoxy]ethyl N-(2-hydroxyethyl)carbamate
• CAS: 6311-12-2
• 化学式: C₁₀H₂₀N₂O₇
• 分子量: 280.28
• InChiKey: CESPSFZCPZOJFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Main Chain Acid-Degradable Polymers for the Delivery of Bioactive Materials
  申请人：Frechet Jean M.J.

  公开号：US20090220615A1

  公开（公告）日：2009-09-03

  Novel main chain acid degradable polymer backbones and drug delivery systems comprised of materials capable of delivering bioactive materials to cells for use as vaccines or other therapeutic agents are described. The polymers are synthesized using monomers that contain acid-degradable linkages cleavable under mild acidic conditions. The main chain of the resulting polymers readily degrade into many small molecules at low pH, but remain relatively stable and intact at physiological pH. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and other sites of inflammation.

  本文介绍了一种新型主链酸可降解聚合物骨架和药物传递系统，由能够向细胞输送生物活性物质以用作疫苗或其他治疗剂的材料组成。这些聚合物是使用含有酸可降解键的单体合成的，这些键在温和酸性条件下可被裂解。由此产生的聚合物主链能够在低pH值下迅速降解为许多小分子，但在生理pH下仍相对稳定完整。这些新材料具有共同的特点，即能够在细胞内部体液或溶酶体等常见酸性条件下通过酸水解逐渐降解，从而释放其有效载荷。这些材料还可用于将治疗剂输送到肿瘤和其他炎症部位的酸性区域。
• US8137700B2
  申请人：——

  公开号：US8137700B2

  公开（公告）日：2012-03-20