(4S,5S)-2-Benzyl-4-methyl-5-phenyl-4,5-dihydro-oxazole | 828247-79-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4S,5S)-2-Benzyl-4-methyl-5-phenyl-4,5-dihydro-oxazole
• 英文别名: (4S,5S)-2-benzyl-4-methyl-5-phenyl-4,5-dihydro-1,3-oxazole
• CAS: 828247-79-6
• 化学式: C₁₇H₁₇NO
• 分子量: 251.328
• InChiKey: YKEZWKHZRIDKAF-SUMWQHHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  phenylacetic acid-((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethylamide) 在 copper(II) bis(trifluoromethanesulfonate) 、 N,N'-二异丙基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 以83%的产率得到(4S,5S)-2-Benzyl-4-methyl-5-phenyl-4,5-dihydro-oxazole
  参考文献：
  名称：

  Synthesis of 2-oxazolines mediated by N,N′-diisopropylcarbodiimide

  摘要：

  N-(beta-Hydroxy)amides can be cyclised by reaction with diisopropy1carbodiimide (DIC) to give the corresponding 2-oxazolines in high yields. The reaction requires only very mild Lewis-acid catalysis (5mol% Cu(OTf)(2)) and can be accomplished with simple heating, or in very short reaction times under microwave irradiation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.10.143

文献信息

• Ardabilchi,N. et al., Journal of the Chemical Society. Perkin transactions I, 1979, p. 539 - 543
  作者：Ardabilchi,N. et al.

  DOI：——

  日期：——
• Synthesis of 2-oxazolines mediated by N,N′-diisopropylcarbodiimide
  作者：Stefano Crosignani、Abigail C. Young、Bruno Linclau

  DOI：10.1016/j.tetlet.2004.10.143

  日期：2004.12

  N-(beta-Hydroxy)amides can be cyclised by reaction with diisopropy1carbodiimide (DIC) to give the corresponding 2-oxazolines in high yields. The reaction requires only very mild Lewis-acid catalysis (5mol% Cu(OTf)(2)) and can be accomplished with simple heating, or in very short reaction times under microwave irradiation. (C) 2004 Elsevier Ltd. All rights reserved.