2-Butylsulfanyl-4-methoxymethyl-6-methyl-nicotinonitrile

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-Butylsulfanyl-4-methoxymethyl-6-methyl-nicotinonitrile
• 英文别名: 2-Butylsulfanyl-4-(methoxymethyl)-6-methylpyridine-3-carbonitrile
• 化学式: C₁₃H₁₈N₂OS
• 分子量: 250.365
• InChiKey: SIOSTPAOSSCEPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  71.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯-3-氰基-4-甲氧基甲基-6-甲基吡啶 、 丁硫醇 在 四乙基溴化铵 作用下， 以 乙腈 为溶剂， 以66%的产率得到2-Butylsulfanyl-4-methoxymethyl-6-methyl-nicotinonitrile
  参考文献：
  名称：

  Electrochemical synthesis and studies of substituted 2-thiopyridines

  摘要：

  A series of substituted 2-alkyl(aryl-, hetaryl-)thiopyridines was prepared by cathodic electrolysis of thiols in the presence of 2-chloro-3-cyano-4-methoxymethyl-6-methylpyridine or 4-chloro-6-methyl-3-oxo-1 H-furo[3,4-c]pyridine. The reaction of 3-cyano-4-methoxymethyl-6-methyl-2(1H)-thiopyridone with alkyl halides in the presence of KOH is regioselective and leads to S-alkyl derivatives. The advantages of electrosynthesis for the preparation of 2-alkylthiopyridines fused with 2(5H)-furanone and of 3-aminothieno[2,3-b]pyridines is demonstrated.

  DOI：

  10.1007/bf00700178

文献信息

• Electrochemical synthesis and studies of substituted 2-thiopyridines
  作者：E. A. Kaigorodova、L. D. Konyushkin、M. E. Niyazymbetov、S. N. Kvak、V. N. Zaplishny、V. P. Litvinov

  DOI：10.1007/bf00700178

  日期：1994.12

  A series of substituted 2-alkyl(aryl-, hetaryl-)thiopyridines was prepared by cathodic electrolysis of thiols in the presence of 2-chloro-3-cyano-4-methoxymethyl-6-methylpyridine or 4-chloro-6-methyl-3-oxo-1 H-furo[3,4-c]pyridine. The reaction of 3-cyano-4-methoxymethyl-6-methyl-2(1H)-thiopyridone with alkyl halides in the presence of KOH is regioselective and leads to S-alkyl derivatives. The advantages of electrosynthesis for the preparation of 2-alkylthiopyridines fused with 2(5H)-furanone and of 3-aminothieno[2,3-b]pyridines is demonstrated.