N-(3-methoxypropyl)pentanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(3-methoxypropyl)pentanamide
• 化学式: C₉H₁₉NO₂
• 分子量: 173.25
• InChiKey: LGOISTASKDDABE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• VITAMIN FUNCTIONALIZED GEL-FORMING BLOCK COPOLYMERS FOR BIOMEDICAL APPLICATIONS
  申请人：INTERNATIONAL BUSINESS MACHINES CORPORATION

  公开号：US20180117162A1

  公开（公告）日：2018-05-03

  Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).

  制备了包含以下组成部分的凝胶形成嵌段共聚物：i）主要由二价聚乙二醇链组成的中心亲水性块和ii）通过带有一个或多个氢键形成*—N(H)—*基团连接到中心块的两个外周单碳酸酯或多碳酸酯疏水性块。疏水性块包含一个或多个含维生素的亚单位。这些凝胶形成嵌段共聚物可用于制备各种可生物降解和/或生物相容的水凝胶和有机凝胶药物组合物，特别是抗微生物和/或抗肿瘤药物组合物。水凝胶组合物在药物输送的库存注射中具有实用性。与由聚乙二醇制备的类似水凝胶相比，氢键*—N(H)—*基团提供了凝胶在体内降解之前更长的生命周期，以及与水凝胶相比更延长和控制释放速率的疏水性药物。
• Methods and compositions relating to synthetic beta-1,6 glucosamine oligosaccharides
  申请人：The Brigham and Women's Hospital, Inc.

  公开号：US10034927B2

  公开（公告）日：2018-07-31

  The invention relates to the compositions of synthetic oligo-β-(1→6)-2-amino-2-deoxy-D-glu-copyranosides conjugated to carriers, and methods for making and use same.

  本发明涉及与载体共轭的合成低聚-β-(1→6)-2-氨基-2-脱氧-D-谷氨酰吡喃糖苷的组合物，以及其制造和使用方法。
• METHODS AND COMPOSITIONS RELATING TO SYNTHETIC BETA-1,6 GLUCOSAMINE OLIGOSACCHARIDES
  申请人：Pier Gerald B.

  公开号：US20110150880A1

  公开（公告）日：2011-06-23

  The invention relates to the compositions of synthetic oligo-β-(1→6)-2-amino-2-deoxy-D-glucopyranosides conjugated to carriers, and methods for making and use same.
• US7419656B2
  申请人：——

  公开号：US7419656B2

  公开（公告）日：2008-09-02
• US8492364B2
  申请人：——

  公开号：US8492364B2

  公开（公告）日：2013-07-23