N-(Acetaminomethyl)-acrylsaeureamid | 56113-44-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(Acetaminomethyl)-acrylsaeureamid
• 英文别名: N-(acetamidomethyl)prop-2-enamide
• CAS: 56113-44-1
• 化学式: C₆H₁₀N₂O₂
• 分子量: 142.158
• InChiKey: LJEGDZGGHRBYNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-羟甲基乙酰胺 、 丙烯酰胺 在 盐酸 、 sodium nitrite 作用下， 生成 N-(Acetaminomethyl)-acrylsaeureamid
  参考文献：
  名称：

  Hydrophobic Compounds and Polymers from Long Chain Alkanamide-Formaldehyde Condensation Reactions

  摘要：

  DOI：

  10.1021/jo01070a094

文献信息

• [EN] EZH2 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS D'EZH2 ET LEURS UTILISATIONS
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2017184999A1

  公开（公告）日：2017-10-26

  The present disclosure provides compounds of any one of Formulae (I), (II), and (III). The compounds described herein are inhibitors of histone methyltransferases (e.g., enhancer of zeste homolog 1 (EZHl) and enhancer of zeste homolog 2 (EZH2)) and are useful in treating and/or preventing a broad range of diseases (e.g., proliferative diseases). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

  本公开提供了任一式(I)、(II)和(III)中的化合物。本文描述的这些化合物是组蛋白甲基转移酶（例如，增强子of zeste同源物1（EZHl）和增强子of zeste同源物2（EZH2））的抑制剂，并可用于治疗和/或预防广泛范围的疾病（例如，增殖性疾病）。本公开还提供了包括或使用本文描述的化合物的药物组合物、试剂盒、方法和用途。
• Antagonists of the bradykinin B1 receptor
  申请人：Ng Gordon

  公开号：US20050215470A1

  公开（公告）日：2005-09-29

  The present invention relates to certain biologically active peptides and conjugated peptides which can be used as therapeutics or prophylactics against diseases or conditions linked to B1 as the causative agent. In a preferred embodiment of the invention biologically active PEG-conjugated peptides are provided. In one aspect of the present invention, pharmacologically active PEG-conjugated peptides of the present invention are useful to treat inflammation or pain.

  本发明涉及某些具有生物活性的肽和共轭肽，可用作治疗或预防与B1作为致病因素相关的疾病或病况的药物。在本发明的一个优选实施例中，提供了具有生物活性的PEG共轭肽。在本发明的一个方面中，本发明的药理活性PEG共轭肽可用于治疗炎症或疼痛。
• Method of conjugating aminothiol containing molecules to vehicles
  申请人：D'Amico C. Derin

  公开号：US20060199812A1

  公开（公告）日：2006-09-07

  The present invention relates to a novel chemical process that provides novel vehicle derivatives that are exceptional 1,2- or 1,3-aminothiol specific reagents for conjugation to unprotected targeted compounds (e.g., polypeptides, peptides, or organic compounds) having or modified to have a 1,2- or 1,3 aminothiol group. The invention further relates to the methods of using novel water-soluble polymer derivatives and conjugates thereof.

  本发明涉及一种新型化学过程，提供了新型车载衍生物，这些衍生物是杰出的1,2-或1,3-氨基硫醇特异性试剂，可用于与未保护的靶向化合物（例如多肽，肽或有1,2-或1,3-氨基硫醇基团的有机化合物）结合。本发明还涉及使用新型水溶性聚合物衍生物及其共轭物的方法。
• pH-indicating material and cat litter containing same
  申请人：ANITOX CORPORATION

  公开号：EP0569232A1

  公开（公告）日：1993-11-10

  A pH-indicating material capable of undergoing a clearly visually detectable color transition at a desired pH, e.g., at a pH at or below about 5.6 and/or at a pH at or above about 7.6. When the pH-indicating material is wetted on its surface with liquid animal dross, particularly animal urine, such as cat urine, the pH-indicating material will undergo a clearly visible color transition at a urine-problematic pH, e.g., acidic or alkaline. The pH-indicating material is maintained on an inert carrier, separate from the cat litter material itself, so that the cat litter material does not chemically interfere with the urine pH-induced color transition provided by the dye(s) in the coating material, and so that the color transition is an exclusive result of the pH of the contacting animal urine, without pH interference from the litter material. In a preferred embodiment, the pH-indicating material is admixed with any cat litter material and has dual indicators that provide one color transition at a low pH and a different color transition at a high pH so that acidic or alkaline animal urine problems can be visibly detected upon contact between the animal urine and the pH-indicating material.

  一种 pH 值指示材料，能够在所需的 pH 值（例如，pH 值为 5.6 或低于 5.6 和/或 pH 值为 7.6 或高于 7.6）下发生清晰可见的颜色转变。当 pH 值指示材料的表面被液态动物粪便，特别是动物尿液（如猫尿）浸湿时，pH 值指示材料将在尿液问题的 pH 值（如酸性或碱性）下发生清晰可见的颜色转变。pH 指示材料保存在惰性载体上，与猫砂材料本身分开，这样猫砂材料就不会对涂层材料中的染料所提供的由尿液 pH 值引起的颜色转换产生化学干扰，从而使颜色转换完全由接触的动物尿液的 pH 值决定，而不受猫砂材料 pH 值的干扰。在一个优选的实施方案中，pH 值指示材料与任何猫砂材料混合，并具有双指示剂，在低 pH 值时提供一种颜色转换，在高 pH 值时提供另一种颜色转换，这样，当动物尿液与 pH 值指示材料接触时，酸性或碱性动物尿液问题就能被明显检测出来。
• Method of improving the contaminant resistance of a smectite clay
  申请人：AMCOL INTERNATIONAL CORPORATION

  公开号：EP0645181A2

  公开（公告）日：1995-03-29

  There is disclosed a method of treating a water-swellable clay after the clay has been mined and dried to improve its properties when in contact with contaminated water. After the common initial drying of the clay to a moisture content of 12% by weight or less, the clay is impregnated with an aqueous solution containing a dissolved, water-soluble polymer, in an amount of at least about 0.5% by weight based on the dry weight of the clay, and the clay is wetted to a moisture content of more than 12% by weight, preferably at least about 15% or more, based on the dry weight of the clay, and then redried to a moisture content of 12% by weight or less, based on the dry weight of the clay. This rewetting step to hydrate and polymer-impregnate the clay, and then redrying the clay, unexpectedly improves the contaminated water absorbency, and viscosity properties when the clay is in contact with contaminated water; unexpectedly increases the rheology properties of the clays for oil well drilling fluids and lost circulation fields when contaminated water is encountered during drilling, enhances the clay properties when used as a suspending agent in the cosmetics and pharmaceutical industries when the composition contains a dissolved, inorganic salt and/or an organic liquid; and provides unexpectedly increased contaminated water-absorption in forming water-swellable clay-based water barriers.

  本发明公开了一种在粘土开采和干燥后对其进行处理的方法，以改善粘土与受污染的水接触时的性能。在将粘土初步干燥至含水量不超过 12% （以重量计）之后，用含有溶解的水溶性聚合物的水溶液浸渍粘土，浸渍量至少为粘土干重的 0.5%（以重量计），然后将粘土润湿至含水量超过 12%（以重量计），最好至少为 15%（以重量计）或更高（以粘土干重为基础），然后再干燥至含水量不超过 12%（以重量计）（以粘土干重为基础）。这一重新润湿步骤使粘土水化并浸渍聚合物，然后重新干燥粘土，意外地改善了粘土与污染水接触时的污染水吸收性和粘度特性；当钻井过程中遇到受污染的水时，意外地提高了粘土在油井钻井液和失水循环油田中的流变特性；当组合物含有溶解的无机盐和/或有机液体时，提高了粘土在化妆品和制药业中用作悬浮剂的特性；以及在形成可吸水的粘土基水屏障时，意外地提高了受污染水的吸收性。