(3R)-3-amino-4-chloro-1,3-dihydroindol-2-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3R)-3-amino-4-chloro-1,3-dihydroindol-2-one
• 化学式: C₈H₇ClN₂O
• 分子量: 182.61
• InChiKey: RDMXTPWBHNCLGF-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Inhibitors of cysteine proteases and methods of use thereof
  申请人：Pardes Biosciences, Inc.

  公开号：US11312704B2

  公开（公告）日：2022-04-26

  The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

  本公开提供了具有弹头的化合物，如式 II 化合物，以及它们在治疗医学疾病或紊乱（如病毒感染）中的用途。还提供了药物组合物和制造各种带弹头化合物的方法。这些化合物被认为可抑制蛋白酶，如 3C、CL- 或 3CL 样蛋白酶。
• INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF
  申请人：Pardes Biosciences, Inc.

  公开号：US20210355111A1

  公开（公告）日：2021-11-18

  The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.