4-(N-Methylanilino)-6-chlorpyrimidin | 6303-48-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(N-Methylanilino)-6-chlorpyrimidin
• 英文别名: (6-chloro-pyrimidin-4-yl)-methyl-phenyl-amine；6-Chloro-n-methyl-n-phenylpyrimidin-4-amine
• CAS: 6303-48-6
• 化学式: C₁₁H₁₀ClN₃
• 分子量: 219.673
• InChiKey: HUUWJLRTQFKVSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  sodium;hydride 、 2-丁炔-1-醇 、 4-(N-Methylanilino)-6-chlorpyrimidin 、 氯化铵 在 氯仿 、 水 、 magnesium sulfate 、 compound ( 93 ) 作用下， 以 四氢呋喃 为溶剂， 反应 6.33h， 以to give 0.18 g of 4-(N-methyl-N-phenylamino)-6-(2-butynyloxy)pyrimidine (the present compound (93)), m.p.: 57.6° C.的产率得到4-(N-methyl-N-phenylamino)-6-(2-butynyloxy)pyrimidine
  参考文献：
  名称：

  Pyrimidine compounds and their use

  摘要：

  式（1）的嘧啶类化合物： 其中，R1是C3-C7炔基，可以选择性地被卤素取代；R2和R3独立地是氢或类似物；R4是C3-C7炔氧基，可以选择性地被卤素、选择性地被取代的苯基或类似物取代，具有出色的杀虫效果。

  公开号：

  US06838463B2

文献信息

• PYRIMIDINE COMPOUNDS AND THEIR USE
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP1366026A2

  公开（公告）日：2003-12-03
• PYRIMIDINE COMPOUNDS AND THEIR USE AS PESTICIDES
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP1366026B1

  公开（公告）日：2004-12-01
• 2,4 (4,6) PYRIMIDINE DERIVATIVES
  申请人：Freyne Eddy Jean Edgard

  公开号：US20100160310A1

  公开（公告）日：2010-06-24

  The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z 1 and Z 2 represent NH; Y represents —C 3-9 alkyl-, —C 3-9 alkenyl-, —C 1-5 alkyl-NR 6 —C 1-5 alkyl-, —C 1-5 alkyl-NR 7 —CO—C 1-5 alkyl-, —C 1-6 alkyl-CO—NH—, —C 1-6 alkyl-NH—CO—, —C 1-2 alkyl-CO-Het 10 -CO—, —C 1-3 alkyl-NH—CO-Het 3 -, -Het 4 -C 1-3 alkyl-CO—NH—C 1-3 alkyl-, —C 1-2 alkyl-NH—CO-L 1 -NH—, —NH—CO-L 2 -NH—, —C 1-2 alkyl-CO—NH-L 3 -CO—, —C 1-2 alkyl-NH—CO-L 1 -NH—CO—C 1-3 alkyl-, —C 1-2 alkyl-CO—NH-L 3 -CO—NH—C 1-3 alkyl-, —C 1-2 alkyl-NR 11 —CH 2 —CO—NH—C 1-3 alkyl-, Het 5 -CO—C 1-2 alkyl-, (C 1-5 alkyl-CO—NH—C 1-3 alkyl-CO—NH, —C 1-5 alkyl-NR 13 —CO—C 1-3 alkyl-NH—, —C 1-3 alkyl-NH—CO-Het 27 -CO—, or —C 1-3 alkyl-CO-Het 28 -CO—NH—; X 1 represents a direct bond, O, —O—C 1-2 alkyl-, —CO—C 1-2 alkyl-, —NR 16 —C 1-2 alkyl-, —CO—NR 17 —, Het 23 -C 1-2 alkyl- or C 1-2 alkyl; X 2 represents a direct bond, O, —O—C 1-2 alkyl-, —CO—C 1-2 alkyl-, —NR 18 —C 1-2 alkyl-, —CO—NR 19 —, Het 24 —C 1-2 alkyl- or C 1-2 alkyl; R 1 and R 5 each independently represent hydrogen, halo, C 1-6 alkyloxy- or C 1-6 alkyloxy- substituted with Het 1 or C 1-4 alkyloxy-; R 2 and R 4 each independently represent hydrogen or halo; R 3 represents hydrogen or cyano; R 6 , R 7 , R 13 , R 17 and R 19 represent hydrogen; R 11 represents hydrogen or C 1-4 alkyl; R 16 and R 18 represent hydrogen, C 1-4 alkyl or Het 17 -C 1-4 alkyl-; L 1 , L 2 and L 3 each independently represents C 1-8 alkyl optionally substituted with one or where possible two or more substituents selected from phenyl, methylsulfide, cyano, polyhaloC 1-4 alkyl-phenyl-, C 1-4 alkyloxy, pyridinyl, mono- or di(C 1-4 alkyl)-amino- or C 3-6 cycloalkyl; Het 1 , Het 2 , Het 17 each independently represent morpholinyl, oxazolyl, isoxazolyl, or piperazinyl; Het 3 , Het 4 , Het 5 each independently represent morpholinyl, piperazinyl, piperidinyl or pyrrolidinyl; Het 10 represents piperazinyl, piperidinyl, pyrrolidinyl or azetidinyl; Het 22 represents morpholinyl, oxazolyl, isoxazolyl or piperazinyl wherein said Het 22 is optionally substituted with C 1-4 alkyl; Het 23 and Het 24 each independently represent a heterocycle selected from pyrrolidinyl, piperazinyl or piperidinyl wherein said Het 23 or Het 24 are optionally substituted with Het 22 -carbonyl; Het 27 and Het 28 each independently represent a heterocycle selected from morpholinyl, piperazinyl, piperidinyl or pyrrolidinyl.
• US6838463B2
  申请人：——

  公开号：US6838463B2

  公开（公告）日：2005-01-04
• US7291730B2
  申请人：——

  公开号：US7291730B2

  公开（公告）日：2007-11-06