N-(6-氨基己基)丙酰胺 | 136364-63-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-(6-氨基己基)丙酰胺
• 中文别名: 2-氯-3-碘喹啉
• 英文名称: propionyl-hexamethylenediamine
• 英文别名: propanoylhexamethylenediamine；N-(6-aminohexyl)propanamide
• CAS: 136364-63-1
• 化学式: C₉H₂₀N₂O
• 分子量: 172.271
• InChiKey: CVCQQJGUCCMIBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] COMPOUNDS AND METHODS FOR PURIFICATION OF SERINE PROTEASES<br/>[FR] COMPOSÉS ET PROCÉDÉS DE PURIFICATION DE SÉRINE PROTÉASES
  申请人：PORTOLA PHARM INC

  公开号：WO2014106128A1

  公开（公告）日：2014-07-03

  Disclosed herein are compounds, compositions, methods and kits for purifying a protease and serine proteases purified with the compounds, compositions and methods.

  本文揭示了用于纯化蛋白酶的化合物、组合物、方法和试剂盒，以及用这些化合物、组合物和方法纯化的丝氨酸蛋白酶。
• NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF
  申请人：S&T Global Inc.

  公开号：US20130210704A1

  公开（公告）日：2013-08-15

  The present invention relates to a compound of the Formula (I)): or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, and hair loss.

  本发明涉及公式(I)的化合物或其药学上可接受的盐，其中符号如规范中所定义；以及包含该化合物的制药组合物，用于治疗或预防病毒感染、炎症、干眼症、中枢神经系统疾病、心血管疾病、癌症、肥胖症、糖尿病、肌肉营养不良和脱发的方法。
• Monosubstituted dithiooxamide compounds and their use
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0434213A1

  公开（公告）日：1991-06-26

  An N-(monosubstituted)dithiooxamide compound of the formula: wherein R3 comprises: (a) an alkyl or aralkyl group having 11 or more carbon atoms; or (b) a group of the structure -R4-Y-R5 wherein: (i) when Y is a functional group selected from the group consisting of -N(R6)C(O)-, -C(O)N-(R6)-, -N(RG)-, -N(RG)C(0)0-, -OC(O)N(R6)-, and -N(R6)C(O)N(R7), wherein R6 and R7 are independently hydrogen, or an alkyl or aralkyl group having 1 to 12 carbon atoms: R4 is a divalent alkyl or divalent aralkyl group having 1 to 12 carbon atoms; R5 is hydrogen, or an alkyl or aralkyl group having 1 to 20 carbon atoms; and, the total number of carbon atoms in R4 plus R5 is at least 7; or (ii) when Y is a functional group selected from the group consisting of -OC(O)-, -C(O)O-, and -OC(O)O-: R4 is a divalent alkyl or divalent aralkyl group having 1 to 12 carbon atoms; R5 is hydrogen, or an alkyl or aralkyl group having 1 to 20 carbon atoms; and, the total number of carbon atoms in R4 plus R5 is at least 9. Preferred materials are those for which when the monosubstituent dithiooxamide is complexed with a transition metal cation, the resulting polymer is substantially a dark, i.e., blue or blue-black color. Carbonless paper constructions involving use of N-(monosubstituted)dithiooxamides to advantage are described.

  一种 N-(单取代)二硫代草酰氨化合物，其式如下 其中 R3 包括 (a) 具有 11 个或更多碳原子的烷基或芳烷基；或 (b) 结构为 -R4-Y-R5 的基团，其中(i) 当 Y 是选自以下组别的官能团时：-N(R6)C(O)-、-C(O)N-(R6)-、-N(RG)-、-N(RG)C(0)0-、-OC(O)N(R6)- 和-N(R6)C(O)N(R7)，其中 R6 和 R7 独立地是氢、或具有 1 至 12 个碳原子的烷基或芳烷基：R4 是具有 1 至 12 个碳原子的二价烷基或二价芳烷基；R5 是氢、或具有 1 至 20 个碳原子的烷基或芳烷基；且 R4 加 R5 中的碳原子总数至少为 7；或 (ii) 当 Y 是选自-OC(O)-、-C(O)O-和-OC(O)O-的官能团时：R4 是具有 1 至 12 个碳原子的二价烷基或二价芳烷基；R5 是氢或具有 1 至 20 个碳原子的烷基或芳烷基；且 R4 加 R5 中的碳原子总数至少为 9。 当单取代基二硫代草酰氨与过渡金属阳离子络合时，得到的聚合物基本上呈深色，即蓝色或蓝黑色，这种材料是首选材料。本文介绍了使用 N-（单取代）二硫代恶酰胺的无碳纸结构。
• Preparation of monosubstituted dithiooxamide compounds
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0431783A1

  公开（公告）日：1991-06-12

  This invention relates to the synthesis of N-­(monosubstituted)dithiooxamides by the transamination of dithiooxamide. Preferred methods, according to the present invention, take advantage of the discovery that yields of N-(monosubstituted)dithiooxamides can be improved in the Wallach Reaction by: controlling the temperature of the reaction mixture; optimizing the initial concentration of the reactants; adding an effective amount of acid in the quenching or processing procedure; and/or, optionally, adding an effective amount of certain nitrogen bases to the reaction mixture.

  本发明涉及通过二硫代草酰氨的反式合成 N-(单取代)二硫代草酰氨。根据本发明，优选的方法利用了以下发现：通过控制反应混合物的温度；优化反应物的初始浓度；在淬火或处理过程中加入有效量的酸；和/或，选择性地在反应混合物中加入有效量的某些氮碱，可以提高瓦拉几反应中 N-（单取代）二硫代恶酰胺的产量。
• Polyacetal resin composition
  申请人：——

  公开号：US20010007006A1

  公开（公告）日：2001-07-05

  A polyacetal resin composition comprising 30-90% by weight of polyacetal copolymer (A) having a melt index of less than 1.0 g/10 min. and 70-10% by weight of polyacetal copolymer (B) having a melt index of 1.0-100 g/10 min., both melting points of (A) and (B) being 155°-162° C., or a difference in melting point between (A) and (B) being not less than 6° C., has distinguished toughness and creep resistance.

  一种聚缩醛树脂组合物含有 30-90% （重量百分比）熔融指数小于 1.0 克/10 分钟的聚缩醛共聚物（A）和 70-10% （重量百分比）熔融指数为 1.0-100 克/10 分钟的聚缩醛共聚物（B），（A）和（B）的熔点均为 155°-162°C，或（A）和（B）的熔点差不小于 6°C，该组合物具有出色的韧性和抗蠕变性。