tetrakis-(4-methoxy-phenyl)-succinonitrile | 7142-92-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tetrakis-(4-methoxy-phenyl)-succinonitrile
• 英文别名: 1.1.2.2-Tetrakis-(4-methoxy-phenyl)-1.2-dicyan-aethan；Tetrakis-(4-methoxy-phenyl)-bernsteinsaeure-dinitril；2,2,3,3-Tetrakis(4-methoxyphenyl)butanedinitrile
• CAS: 7142-92-9
• 化学式: C₃₂H₂₈N₂O₄
• 分子量: 504.585
• InChiKey: DPFOPUKOKWMDFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  84.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tetrakis-(4-methoxy-phenyl)-succinonitrile 在 苯乙烯 作用下， 生成 2,2,5,5-tetrakis-(4-methoxy-phenyl)-3-phenyl-adiponitrile
  参考文献：
  名称：

  387.芳基偶氮三芳基甲烷和四芳基琥珀二腈作为加成聚合反应的催化剂

  摘要：

  DOI：

  10.1039/jr9490001807
• 作为产物：
  描述：

  2,2-双(4-甲氧基苯基)乙腈 在 sodium hydroxide 、 potassium hexacyanoferrate(III) 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 以84.2%的产率得到tetrakis-(4-methoxy-phenyl)-succinonitrile
  参考文献：
  名称：

  二芳基乙腈作为分子探针通过自由基链转移机制检测大分子状态的高分子机械物质

  摘要：

  自高分子科学开始以来，了解机械应力对高分子链的影响一直是基础和重要的研究课题。在许多情况下，已经研究了通过溶液中聚合物链的均相裂解产生的机械力学的检测。然而，由于其高反应性，对大块机械药的检测仍然受到限制。本文中，我们提出了一种创新的策略，可以使用产生相对稳定的荧光自由基的链转移剂作为分子探针，以可视方式和定量方式检测机械力学。通过二芳基乙腈化合​​物作为自由基分子转移机理的荧光分子探针，成功地检测了聚苯乙烯样品的球磨产生的机械力学。

  DOI：

  10.1002/anie.202013180

文献信息

• Water absorbing polymer
  申请人：——

  公开号：US20020039655A1

  公开（公告）日：2002-04-04

  A process for producing a substantially dry polymer particle powder. A mixture of polymerization reagents is formed from a mixture of at least one monomer source and a solvent selected from the group consisting essentially of water and organic solvents and an initiator source. The mixture of polymerization reagents is sprayed into a heated, controlled atmosphere, forming droplets of the mixture which are allowed to fall through the heated, controlled atmosphere for a sufficient period of time to obtain a desired degree of polymerization. The solvent is continuously evacuated from the atmosphere during the polymerization process.

  一种生产基本干燥的聚合物颗粒粉末的工艺。聚合试剂混合物由至少一种单体源和一种溶剂的混合物形成，该溶剂选自主要由水、有机溶剂和引发剂源组成的组。将聚合试剂混合物喷入加热的可控气氛中，形成混合物液滴，让其在加热的可控气氛中下落足够长的时间，以获得所需的聚合度。在聚合过程中，溶剂不断从大气中排出。
• The endothelin receptor antagonist, L-754,142 does not prevent cyclosporine a-induced osteopenia in rats
  作者：B. R. Sodam、E. M. K. Awumey、W. H. Sampson、S. Epstein

  DOI：10.1007/bf02678150

  日期：2001.2

  Cyclosporine A (CsA) is a potent immunosuppressive agent widely used to prevent allograft rejection. In vivo administration of CsA is associated with the development of high-turnover osteopenia. Endothelin-l (ET), a vasoconstrictive peptide, has been implicated in CsA-induced nephrotoxicty and hypertension. Recent evidence suggests that endothelin plays a pivotal role in bone metabolism. The present study was designed to investigate whether L-754,142 (ETRA), the combined endothelin A and B receptor antagonist, when given to rats, would favorably modify the bone loss caused by CsA. Fifty, 5-month-old male Sprague-Dawley rats were randomly divided into five groups of 10 rats each. The first group served as a basal control. The remaining four groups received, by daily gavage for 28 days, (1) a combined CsA and ETRA vehicle, (2) CsA, 10 mg/kg, (3) ETRA, 30 mg/kg, and (4) CsA, 10 mg/kg and ETRA, 30 mg/kg, respectively. Rats were weighed and venous blood was collected on days 0, 14, 28 for determination of BUN, creatinine, calcium, PTH, osteocalcin, and 1,25(OH)(2) D. Tibiae, after double labeling, were removed following sacrifice for histomorphometry. Both CsA-treated rats and CsA/ETRA-treated rats demonstrated trabecular osteopenia with raised serum osteocalcin, and 1,25(OH)(2)D levels when compared to control animals (P < 0.05). Rats given CsA alone developed renal impairment, as shown by an increased BUN. The combination group did not develop renal impairment. The results suggest that endothelin may contribute to the development of CsA-induced nephrotoxicity, which was prevented by ETRA, but does not seem to play a role in CsA-induced osteopenia.
• A POLYMERIZATION PROCESS AND APPARATUS
  申请人：Freeman, Clarence S.

  公开号：EP0873185B1

  公开（公告）日：2003-05-21
• Polymerization process, apparatus mid polymer
  申请人：Waterguard Telecommunications Technologies, Inc. a Texas Corporation

  公开号：US20020193546A1

  公开（公告）日：2002-12-19

  A process for producing a substantially dry polymer particle powder. A mixture of polymerization reagents is formed from a mixture of at least one monomer source and a solvent selected from the group consisting essentially of water and organic solvents and an initiator source. The mixture of polymerization reagents is sprayed into a heated, controlled atmosphere, forming droplets of the mixture which are allowed to fall through the heated, controlled atmosphere for a sufficient period of time to obtain a desired degree of polymerization. The solvent is continuously evacuated from the atmosphere during the polymerization process.
• US6291605B1
  申请人：——

  公开号：US6291605B1

  公开（公告）日：2001-09-18