2,2-dimethyl-propionic acid 5-formyl-2-(4-formyl-phenoxy)-phenyl ester | 1027075-64-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-dimethyl-propionic acid 5-formyl-2-(4-formyl-phenoxy)-phenyl ester
• 英文别名: [5-Formyl-2-(4-formylphenoxy)phenyl] 2,2-dimethylpropanoate
• CAS: 1027075-64-4
• 化学式: C₁₉H₁₈O₅
• 分子量: 326.349
• InChiKey: APBJWFOMKUCVNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,2-dimethyl-propionic acid 5-formyl-2-(4-formyl-phenoxy)-phenyl ester 、 2,4-二甲氧基苯乙酮 在 正丁基锂 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.5h， 以39%的产率得到5-(3-(2,4-dimethoxyphenyl)-1-hydroxy-3-oxopropyl)-2-(4-(3-(2,4-dimethoxyphenyl)-1-hydroxy-3-oxopropyl)phenoxy)phenyl pivalate
  参考文献：
  名称：

  Synthesis and antibacterial activity of littorachalcone and related diphenyl ethers

  摘要：

  Littorachalcone (1) and diacid 10 were synthesized by direct routes. The antibacterial activity of 1, 10 and synthetic precursors were evaluated. Dialdehyde 3a showed potent antibacterial activity. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2008.02.082
• 作为产物：
  描述：

  在 ammonium cerium(IV) nitrate 作用下， 以 水 、 溶剂黄146 为溶剂， 以63%的产率得到2,2-dimethyl-propionic acid 5-formyl-2-(4-formyl-phenoxy)-phenyl ester
  参考文献：
  名称：

  Synthesis and antibacterial activity of littorachalcone and related diphenyl ethers

  摘要：

  Littorachalcone (1) and diacid 10 were synthesized by direct routes. The antibacterial activity of 1, 10 and synthetic precursors were evaluated. Dialdehyde 3a showed potent antibacterial activity. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2008.02.082

文献信息

• Synthesis and antibacterial activity of littorachalcone and related diphenyl ethers
  作者：George A. Kraus、Ganesh Kumar、Gregory Phillips、Kris Michalson、Maria Mangano

  DOI：10.1016/j.bmcl.2008.02.082

  日期：2008.4

  Littorachalcone (1) and diacid 10 were synthesized by direct routes. The antibacterial activity of 1, 10 and synthetic precursors were evaluated. Dialdehyde 3a showed potent antibacterial activity. (C) 2008 Published by Elsevier Ltd.