1-((E)-4-(3,4-dimethoxyphenyl)-3-nitro-1-(phenylsulfonyl)-but-3-enylsulfonyl)benzene | 1431708-80-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-((E)-4-(3,4-dimethoxyphenyl)-3-nitro-1-(phenylsulfonyl)-but-3-enylsulfonyl)benzene
• 英文别名: 4-[(E)-4,4-bis(benzenesulfonyl)-2-nitrobut-1-enyl]-1,2-dimethoxybenzene
• CAS: 1431708-80-3
• 化学式: C₂₄H₂₃NO₈S₂
• 分子量: 517.581
• InChiKey: OGPIVOXWIKUZMO-XDJHFCHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  149
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,2-dimethoxy-4-(2-nitro-vinyl)-benzene 、 1,1-双(苯基磺酰基)乙烯 在 咪唑 、 lithium chloride 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 以85%的产率得到1-((E)-4-(3,4-dimethoxyphenyl)-3-nitro-1-(phenylsulfonyl)-but-3-enylsulfonyl)benzene
  参考文献：
  名称：

  Rauhut–Currier Reaction of Nitroalkenes with Vinyl Sulfones

  摘要：

  The Rauhut-Currier reaction between nitroalkenes and vinyl sulfones has been successfully carried out for the first time. The reaction proceeds in the presence of an imidazole/LiCl catalyst system in dioxane to provide the adducts possessing a synthetically useful 1-bis-sulfonyl-3-nitroalkene moiety in good to excellent yield. A one-pot transformation of the products to beta-sulfonyl-alpha,beta-unsaturated ketoximes has also been demonstrated.

  DOI：

  10.1021/jo400528j

文献信息

• Rauhut–Currier Reaction of Nitroalkenes with Vinyl Sulfones
  作者：Rahul Kumar、Tarun Kumar、Shaikh M. Mobin、Irishi N. N. Nambothiri

  DOI：10.1021/jo400528j

  日期：2013.5.17

  The Rauhut-Currier reaction between nitroalkenes and vinyl sulfones has been successfully carried out for the first time. The reaction proceeds in the presence of an imidazole/LiCl catalyst system in dioxane to provide the adducts possessing a synthetically useful 1-bis-sulfonyl-3-nitroalkene moiety in good to excellent yield. A one-pot transformation of the products to beta-sulfonyl-alpha,beta-unsaturated ketoximes has also been demonstrated.