4-butyl-N-[(4-chlorophenyl)methyl]aniline | 1036471-26-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-butyl-N-[(4-chlorophenyl)methyl]aniline
• CAS: 1036471-26-7
• 化学式: C₁₇H₂₀ClN
• 分子量: 273.806
• InChiKey: QYPKRRJGGVNGAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-正丁基苯胺 、 4-氯苯甲醛 在 三甲基氯硅烷 、 二氢吡啶 作用下， 以 二氯甲烷 为溶剂， 以90%的产率得到4-butyl-N-[(4-chlorophenyl)methyl]aniline
  参考文献：
  名称：

  Highly chemoselective reductive amination by one pot reaction of aldehydes, amines and Dihydropyridine Catalyzed by TMSCl

  摘要：

  More efficient, cost effective and metal free DHP/TMSCl system for one pot reductive amination of aldehydes was developed. The method allows the efficient one pot synthesis of structurally diverse amines with Hantzsch ester as the hydrogen source in the presence of trimethylsilyl chloride as a catalyst in high to quantitative yields under mild conditions.

  DOI：

  10.1007/bf03246028

文献信息

• Highly chemoselective reductive amination by one pot reaction of aldehydes, amines and Dihydropyridine Catalyzed by TMSCl
  作者：N. Azizi、A. R. Khajeh Amiri、H. Ghafuri、M. R. Saidi、M. Bolourtchian

  DOI：10.1007/bf03246028

  日期：2010.6

  More efficient, cost effective and metal free DHP/TMSCl system for one pot reductive amination of aldehydes was developed. The method allows the efficient one pot synthesis of structurally diverse amines with Hantzsch ester as the hydrogen source in the presence of trimethylsilyl chloride as a catalyst in high to quantitative yields under mild conditions.