PyWWOH | 1257657-74-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: PyWWOH
• 英文别名: picolinoyl-Trp-Trp-OH；(2S)-3-(1H-indol-3-yl)-2-[[(2S)-3-(1H-indol-3-yl)-2-(pyridine-2-carbonylamino)propanoyl]amino]propanoic acid
• CAS: 1257657-74-1
• 化学式: C₂₈H₂₅N₅O₄
• 分子量: 495.538
• InChiKey: MGDSVJQWYXEFNE-DQEYMECFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  140
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  PyWWOMe 在 甲醇 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 4.0h， 以69%的产率得到PyWWOH
  参考文献：
  名称：

  A synthetic ditryptophan conjugate that rescues bacteria from mercury toxicity through complexation

  摘要：

  The synthesis of ditryptophan-pyridine conjugates and their binding to mercury ions is described. Conjugate 3 shows an excellent ability to sequester mercury from solution and rescue bacterial growth in a concentration-dependent survival assay. It is proposed that such compounds, composed primarily of bioessential/biodegradable components, could be potentially used as sequestrating agents for the removal of Hg(II) ions in detoxification strategies. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.047

文献信息

• A synthetic ditryptophan conjugate that rescues bacteria from mercury toxicity through complexation
  作者：Sudipta Mondal、Shiv Swaroop、Ramanathan Gurunath、Sandeep Verma

  DOI：10.1016/j.tetlet.2010.09.047

  日期：2010.11

  The synthesis of ditryptophan-pyridine conjugates and their binding to mercury ions is described. Conjugate 3 shows an excellent ability to sequester mercury from solution and rescue bacterial growth in a concentration-dependent survival assay. It is proposed that such compounds, composed primarily of bioessential/biodegradable components, could be potentially used as sequestrating agents for the removal of Hg(II) ions in detoxification strategies. (C) 2010 Elsevier Ltd. All rights reserved.