carbamic acid-(1-ethyl-butyl ester) | 6319-46-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: carbamic acid-(1-ethyl-butyl ester)
• 英文别名: Carbamidsaeure-(1-aethyl-butylester)；Carbamidsaeure-(aethyl-propyl-carbin)-ester；Hexan-3-yl carbamate
• CAS: 6319-46-6
• 化学式: C₇H₁₅NO₂
• mdl: MFCD19204562
• 分子量: 145.202
• InChiKey: GUMWTWBEQCYCCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR ANEMIA COMPRISING TETRAHYDROQUINOLINE COMPOUND AS ACTIVE INGREDIENT
  申请人：Ashikawa Masanori

  公开号：US20120004197A1

  公开（公告）日：2012-01-05

  Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed is and EPO production enhancer and/or a hemoglobin production enhancer comprising a 1-acyl-4-(substituted oxy, substituted amino, or substituted thio)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by general formula (1) [wherein R 1 , R 2 , R 2′ , R 3 and R 3′ independently represent a hydrogen atom, a C 1-6 alkyl group, or the like; R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 independently represent a hydrogen atom, a halogen atom, a C 1-6 alkyl group, or the like; A represents N—R 11 , a sulfur atom, or an oxygen atom; R 11 represents a hydrogen atom, a C 1-6 alkyl group, or the like; B represents a C 6-14 aryl group, or a 5- to 10-membered heterocyclic group; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

  揭示了一种具有低分子量的化合物，具有增强EPO产生和/或增强血红蛋白产生活性的化合物。具体揭示了一种EPO产生增强剂和/或血红蛋白产生增强剂，包括1-酰基-4-(取代氧基、取代氨基或取代硫基)-1,2,3,4-四氢喹啉衍生物，更具体地说是由通式(1)表示的四氢喹啉化合物【其中R1、R2、R2'、R3和R3'独立地表示氢原子、C1-6烷基或类似物；R4、R5、R6、R7、R8、R9和R10独立地表示氢原子、卤素原子、C1-6烷基或类似物；A表示N—R11、硫原子或氧原子；R11表示氢原子、C1-6烷基或类似物；B表示C6-14芳基或5-至10-成员杂环基；n表示0或1的整数】，四氢喹啉化合物的盐，或四氢喹啉化合物或其盐的溶剂化合物。
• PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR ANEMIA, COMPRISING TETRAHYDROQUINOLINE COMPOUND AS ACTIVE INGREDIENT
  申请人：Kowa Company, Ltd.

  公开号：EP2199283A1

  公开（公告）日：2010-06-23

  Disclosed is a low-molecular-weight compound having an EPO production-promoting activity and/or a hemoglobin expression-enhancing activity. Specifically disclosed is an EPO production promoter and/or a hemoglobin expression enhancer comprising a 1-acyl-4-(phenoxy, benzyloxy or phenylamino)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by the general formula (1); [wherein R1, R2, R2', R3 and R3' independently represent a hydrogen atom, a C1-6 alkyl group, or the like; R4, R5, R6, R7, R8, R9 and R10 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or the like; A represents N-R11 or an oxygen atom; R11 represents a hydrogen atom, a C1-6 alkyl group, or the like; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

  本文披露了一种具有促进EPO产生活性和/或增强血红蛋白表达活性的低分子化合物。具体披露了一种EPO产生促进剂和/或血红蛋白表达增强剂，包括1-酰基-4-(苯氧基、苄氧基或苯基氨基)-1,2,3,4-四氢喹啉衍生物，更具体地说是由通式（1）表示的四氢喹啉化合物；[其中R1、R2、R2'、R3和R3'独立地表示氢原子、C1-6烷基或类似物；R4、R5、R6、R7、R8、R9和R10独立地表示氢原子、卤素原子、C1-6烷基或类似物；A表示N-R11或氧原子；R11表示氢原子、C1-6烷基或类似物；n表示0或1的整数]，四氢喹啉化合物的盐，或四氢喹啉化合物或其盐的溶剂结晶体。
• Benzopyran Compound
  申请人：Tsukagoshi Toru

  公开号：US20070299130A1

  公开（公告）日：2007-12-27

  This invention relates to benzopyran compounds of formula (I) wherein X is NR 6 , Y is a bond, SO or SO 2 , Z is C 1-4 alkyl group or phenyl group, W is hydrogen atom, hydroxy group, C 1-6 alkoxy group, a halogen atom, C 1-4 alkyl group or C 1-6 alkylsulfonylamino group, R 1 and R 2 are independently of each other C 1-3 alkyl group, R 3 is hydrogen atom, hydroxy group or methoxy group, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR 7 R 8 , NR 9 , O, S, SO or SO 2 , R 4 is hydrogen atom or C 1-6 alkyl group, R 5 is hydrogen atom, C 1-6 alkyl group, C 3-8 cycloalkyl group, C 3-8 cycloalkenyl group, C 6-14 aryl group or C 2-9 heteroaryl group. These compounds are useful as an anti-arrhythmic agent.

  本发明涉及式（I）的苯并吡喃化合物，其中X为NR6，Y为键，SO或SO2，Z为C1-4烷基或苯基，W为氢原子，羟基，C1-6烷氧基，卤素原子，C1-4烷基或C1-6烷基磺酰氨基，R1和R2分别为C1-3烷基，R3为氢原子，羟基或甲氧基，m为0至4的整数，n为0至4的整数，V为单键，CR7R8，NR9，O，S，SO或SO2，R4为氢原子或C1-6烷基，R5为氢原子，C1-6烷基，C3-8环烷基，C3-8环烯基，C6-14芳基或C2-9杂芳基。这些化合物可用作抗心律失常剂。
• 1-ACYL-4-(PHENOXY, BENZYLOXY, OR PHENYLAMINO)-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES
  申请人：KOWA COMPANY, LTD.

  公开号：US20130172345A1

  公开（公告）日：2013-07-04

  Disclosed is a low-molecular-weight compound having an EPO production-promoting activity and/or a hemoglobin expression-enhancing activity. Specifically disclosed is an EPO production promoter and/or a hemoglobin expression enhancer comprising a 1-acyl-4-(phenoxy, benzyloxy or phenylamino)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by the general formula (1); [wherein R 1 , R 2 , R 2 ′, R 3 and R 3 ′ independently represent a hydrogen atom, a C 1-6 alkyl group, or the like; R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 16 independently represent a hydrogen atom, a halogen atom, a C 1-6 alkyl group, or the like; A represents N—R 11 or an oxygen atom; R 11 represents a hydrogen atom, a C 1-6 alkyl group, or the like; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

  本发明涉及一种低分子量化合物，具有促进EPO产生和/或增强血红蛋白表达的活性。具体揭示了一种EPO产生促进剂和/或血红蛋白表达增强剂，包括1-酰基-4-(苯氧基、苄氧基或苯胺基)-1,2,3,4-四氢喹啉衍生物，更具体地，是由通式(1)表示的四氢喹啉化合物；[其中R1、R2、R2'、R3和R3'独立地表示氢原子、C1-6烷基或类似物；R4、R5、R6、R7、R8、R9和R16独立地表示氢原子、卤素原子、C1-6烷基或类似物；A表示N—R11或氧原子；R11表示氢原子、C1-6烷基或类似物；n表示0或1]，四氢喹啉化合物的盐或四氢喹啉化合物或其盐的溶剂化物。
• SUBSTITUTED BENZOYLAMINOTHIAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME
  申请人：ZERIA PHARMACEUTICAL CO., LTD.

  公开号：EP0934938A1

  公开（公告）日：1999-08-11

  The present invention relates to a substituted benzoylaminothiazole derivative represented by the following formula (I): wherein X represents an imino group which may be substituted by a lower alkyl group, or an oxygen atom, R1 represents a cyano group, a lower alkoxycarbonyl group, a lower alkoxycarbonylamino group, a lower alkylsulfonylamino group, a lower alkanoyl or lower alkylsulfonyl group which may be substituted by a halogen atom, a 1-ureido group, a halo-substituted lower alkyl group or a 2-pyrrolylimino group, R2 and R3 are the same or different and each independently represents a hydrogen atom or a lower alkyl group and m stands for an integer of 2 to 4, or a salt thereof; and a medicament comprising the compound as an effective ingredient. The compound of the invention is useful as a preventive and therapeutic agent for epigastric dyscomfort, nausea, vomiting, heartburn, anorexia, bellyache, abdominal flatulence, chronic gastritis or the like.

  本发明涉及由下式(I)代表的取代苯甲酰氨基噻唑衍生物： 其中 X 代表可被低级烷基或氧原子取代的亚氨基，R1 代表氰基、低级烷氧基羰基、低级烷氧基羰基氨基、低级烷基磺酰基氨基、可被卤素原子取代的低级烷酰基或低级烷基磺酰基、1-脲基、卤代低级烷基或 2-吡咯基亚胺基，R2 和 R3 相同或不同，各自独立地代表氢原子或低级烷基，m 代表 2 至 4 的整数，或其盐；以及包含本发明化合物作为有效成分的药物。本发明的化合物可作为上腹不适、恶心、呕吐、胃灼热、厌食、肚痛、腹部胀气、慢性胃炎或类似疾病的预防和治疗药物。