N-(4-bromo-3-chlorophenyl)-3-(4-(pyrrolidin-1-yl)piperidin-1-yl)-5-(trifluoromethyl)benzamide | 1201592-63-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-bromo-3-chlorophenyl)-3-(4-(pyrrolidin-1-yl)piperidin-1-yl)-5-(trifluoromethyl)benzamide
• 英文别名: N-(4-bromo-3-chlorophenyl)-3-(4-pyrrolidin-1-ylpiperidin-1-yl)-5-(trifluoromethyl)benzamide
• CAS: 1201592-63-3
• 化学式: C₂₃H₂₄BrClF₃N₃O
• 分子量: 530.815
• InChiKey: BXXQIVVJIYKTQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-溴-3-氯苯胺 、 3-(4-(pyrrolidin-1-yl)piperidin-1-yl)-5-(trifluoromethyl)benzoic acid 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-(4-bromo-3-chlorophenyl)-3-(4-(pyrrolidin-1-yl)piperidin-1-yl)-5-(trifluoromethyl)benzamide
  参考文献：
  名称：

  Cell-based optimization of novel benzamides as potential antimalarial leads

  摘要：

  Screening our in-house compound collection using a cell based Plasmodium falciparum proliferation assay we discovered a known pan- kinase inhibitor scaffold as a hit. Further optimization of this series led us to a novel benzamide scaffold which was devoid of human kinase activity while retaining its antiplasmodial activity. The evolution of this compound series leading to optimized candidates with good cellular potency against multiple strains as well as decent in vivo profile is described in this Letter. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.050

文献信息

• COMPOUNDS AND COMPOSITIONS USEFUL FOR THE TREATMENT OF MALARIA
  申请人：Chatterjee Arnab K.

  公开号：US20110144107A1

  公开（公告）日：2011-06-16

  The invention provides a class of compounds of formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent malaria.

  本发明提供了一类I式化合物，包括这些化合物的药物组合物和使用这些化合物治疗或预防疟疾的方法。
• マラリアの処置に有用な化合物および組成物
  申请人：アイアールエム・リミテッド・ライアビリティ・カンパニー

  公开号：JP2011524365A

  公开（公告）日：2011-09-01

  本発明は、マラリアを処置または予防するための、化合物のクラス、かかる化合物を含む医薬組成物およびかかる化合物を使用する方法を提供する。

  本发明提供了一类化合物、含有此类化合物的药物组合物以及使用此类化合物治疗或预防疟疾的方法。
• [EN] COMPOUNDS AND COMPOSITIONS USEFUL FOR THE TREATMENT OF MALARIA<br/>[FR] COMPOSÉS ET COMPOSITIONS UTILES POUR LE TRAITEMENT DE LA MALARIA
  申请人：IRM LLC

  公开号：WO2009152356A2

  公开（公告）日：2009-12-17

  The invention provides a class of compounds of formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent malaria. (I)
• Cell-based optimization of novel benzamides as potential antimalarial leads
  作者：Tao Wu、Advait Nagle、Tomoyo Sakata、Kerstin Henson、Rachel Borboa、Zhong Chen、Kelli Kuhen、David Plouffe、Elizabeth Winzeler、Francisco Adrian、Tove Tuntland、Jonathan Chang、Susan Simerson、Steven Howard、Jared Ek、John Isbell、Xianming Deng、Nathanael S. Gray、David C. Tully、Arnab K. Chatterjee

  DOI：10.1016/j.bmcl.2009.10.050

  日期：2009.12

  Screening our in-house compound collection using a cell based Plasmodium falciparum proliferation assay we discovered a known pan- kinase inhibitor scaffold as a hit. Further optimization of this series led us to a novel benzamide scaffold which was devoid of human kinase activity while retaining its antiplasmodial activity. The evolution of this compound series leading to optimized candidates with good cellular potency against multiple strains as well as decent in vivo profile is described in this Letter. (C) 2009 Elsevier Ltd. All rights reserved.