6-aminopyridine-3-carboxylic acid | 165901-22-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-aminopyridine-3-carboxylic acid
• 英文别名: 6-(2-Sulfanylanilino)pyridine-3-carboxylic acid
• CAS: 165901-22-4
• 化学式: C₁₂H₁₀N₂O₂S
• 分子量: 246.29
• InChiKey: BNUPOROQOAVSEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.2
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-aminopyridine-3-carboxylic acid 在 偶氮二甲酸二乙酯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以76%的产率得到di<2-(pyridine-3-carboxylic acid-6-yl)amino>phenyl disulfide
  参考文献：
  名称：

  A Convenient Synthesis of Pyrido[3,2-b][1,4]bensothiazine Derivatives via Oxidative Ring Closure of 3-Substituted 6-[N-(2-Mercaptophenyl)]aminopyridines

  摘要：

  3-Substituted pyrido[3,2-b] [1,4] benzothiazines were prepared either by heating the disulfide derivatives, which were obtained by a treatment of 3-substituted 6-[N-(2-mercaptophenyl)]aminopyridines with diethyl azodicarboxylate (DEAD) or NBS in DMF at room temperature under the basic conditions or directly by heating the reaction mixture 3-substituted 6-[N-(2-mercaptophenyl)]aminopyridines.

  DOI：

  10.3987/com-94-6951
• 作为产物：
  描述：

  6-氯烟酸 、 2-氨基苯硫醇 在 溶剂黄146 作用下， 反应 24.0h， 以90%的产率得到6-aminopyridine-3-carboxylic acid
  参考文献：
  名称：

  A Convenient Synthesis of Pyrido[3,2-b][1,4]bensothiazine Derivatives via Oxidative Ring Closure of 3-Substituted 6-[N-(2-Mercaptophenyl)]aminopyridines

  摘要：

  3-Substituted pyrido[3,2-b] [1,4] benzothiazines were prepared either by heating the disulfide derivatives, which were obtained by a treatment of 3-substituted 6-[N-(2-mercaptophenyl)]aminopyridines with diethyl azodicarboxylate (DEAD) or NBS in DMF at room temperature under the basic conditions or directly by heating the reaction mixture 3-substituted 6-[N-(2-mercaptophenyl)]aminopyridines.

  DOI：

  10.3987/com-94-6951

文献信息

• Chern Ji-Wang, Wu Kuo-Rong, Heterocycles, 41 (1995) N 3, S 461- 469
  作者：Chern Ji-Wang, Wu Kuo-Rong

  DOI：——

  日期：——
• A Convenient Synthesis of Pyrido[3,2-b][1,4]bensothiazine Derivatives via Oxidative Ring Closure of 3-Substituted 6-[N-(2-Mercaptophenyl)]aminopyridines
  作者：Ji-Wang Chern、Kuo-Rong Wu

  DOI：10.3987/com-94-6951

  日期：——

  3-Substituted pyrido[3,2-b] [1,4] benzothiazines were prepared either by heating the disulfide derivatives, which were obtained by a treatment of 3-substituted 6-[N-(2-mercaptophenyl)]aminopyridines with diethyl azodicarboxylate (DEAD) or NBS in DMF at room temperature under the basic conditions or directly by heating the reaction mixture 3-substituted 6-[N-(2-mercaptophenyl)]aminopyridines.